Drug–drug interactions in nursing home residents: analysis from the COME-ON trial.
Background as a result of the high prevalence of polypharmacy in nursing homes (NHs), nursing home residents (NHRs) are exposed to numerous drug–drug interactions (DDIs) that can lead to adverse drug effects, and increased morbidity and mortality. Objectives to evaluate (i) the prevalence of DDIs am...
| Publicado en: | Age & Ageing Vol. 52; no. 1; pp. 1 - 6 |
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| Autores principales: | , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=161698631&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 161698631 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Jan2023 vid: 52 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 161698631 10.1093/ageing/afac278 ppf: 1 ppct: 5 formats: tig: atl: Drug–drug interactions in nursing home residents: analysis from the COME-ON trial. aug: au: Lion, Simon Evrard, Perrine Foulon, Veerle Spinewine, Anne affil: Clinical Pharmacy Research Group, Louvain Drug Research Institute, UCLouvain , Brussels, Belgium Department of Pharmaceutical and Pharmacological Sciences, KU Leuven , Leuven, Belgium Pharmacy Department, UCLouvain, CHU UCL Namur , Yvoir, Belgium su: Belgium Diseases Randomized controlled trials Drug side effects Prevention of drug side effects Mortality risk factors Cluster sampling Statistics Multiple regression analysis Polypharmacy Inappropriate prescribing (Medicine) Drug interactions Descriptive statistics Research funding Statistical sampling Data analysis sug: subj: Diseases Randomized controlled trials Drug side effects Belgium Marketing Research and Public Opinion Polling Prevention of drug side effects Mortality risk factors Cluster sampling Statistics Multiple regression analysis Polypharmacy Inappropriate prescribing (Medicine) Drug interactions Descriptive statistics Research funding Statistical sampling Data analysis keyword: drug–drug interactions nursing homes older adults older people polypharmacy drug–drug interactions nursing homes older adults older people polypharmacy ab: Background as a result of the high prevalence of polypharmacy in nursing homes (NHs), nursing home residents (NHRs) are exposed to numerous drug–drug interactions (DDIs) that can lead to adverse drug effects, and increased morbidity and mortality. Objectives to evaluate (i) the prevalence of DDIs among NHRs and its evolution over time, and (ii) factors associated with a favourable evolution. Design posthoc analysis of the COME-ON study, a cluster-randomised controlled trial aiming at reducing potentially inappropriate prescriptions in NHs, through the implementation of a complex intervention. Setting and subjects 901 NHRs from 54 Belgian NHs. Methods DDIs were identified using a validated list of 66 potentially clinically relevant DDIs in older adults. We defined a favourable evolution at 15 months as the resolution of at least one DDI present at baseline, without the introduction of any new DDI. Factors associated with a favourable evolution were analysed using multivariable logistic regression. Results at baseline, 475 NHRs (52.7%) were exposed to at least 1 DDI and 225 NHRs (25.0%) to more than one DDI. Most common DDI was 'Concomitant use of at least three central nervous system active drugs'. At 15 months, we observed a 6.3% absolute decrease in DDI prevalence in intervention group, and a 1.0% absolute increase in control group. The intervention, older age and private NH ownership were significantly associated with a favourable DDI evolution. Conclusion a high prevalence of DDI in Belgian NHs was observed, but the COME-ON intervention was associated with a favourable evolution over time. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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