Fibrinogen as a Predictor of Early Neurological Deterioration in Acute Ischemic Stroke – Evidence From the Indian Population.
Background: Early neurological deterioration (END) is a common occurrence in ischemic stroke and contributes significantly to poor outcomes. Although multiple factors that predict END have already been identified, the role of fibrinogen – a key component of the coagulation pathway, is controversial....
| Publicado en: | Journal of Central Nervous System Disease pp. 1 - 9 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2/7/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161761194&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161761194 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11795735 B3L8 jtl: Journal of Central Nervous System Disease issn: 11795735 maglogo: Y pubinfo: dt: 2/7/2023 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 161761194 161761194 161761194 10.1177/11795735231156349 161761194 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Fibrinogen as a Predictor of Early Neurological Deterioration in Acute Ischemic Stroke – Evidence From the Indian Population. aug: au: Mehta, Vishal Sharma, Akhya Jyoti, Divya Prabhakar, Rathod Kumar, Ritesh Guria, Rishi T. Sharma, Chandra B. affil: Department of Medicine, 78602 Rajendra Institute of Medical Sciences, Ranchi, India sug: subj: Fibrinogen Adverse Effects Clinical Deterioration Nervous System Diseases India Ischemic Stroke Outcomes (Health Care) Evaluation Prediction Models Human Odds Ratio Confidence Intervals India Prospective Studies Nonexperimental Studies Scales Blood Glucose Early Diagnosis ab: Background: Early neurological deterioration (END) is a common occurrence in ischemic stroke and contributes significantly to poor outcomes. Although multiple factors that predict END have already been identified, the role of fibrinogen – a key component of the coagulation pathway, is controversial. Objective: To assess the role of fibrinogen in predicting END and poor hospital outcome in patients with acute ischemic stroke. Design: Single-centre prospective observational study. Methods: 141 patients with acute ischemic stroke were analyzed in this prospective observational study from a single tertiary-care hospital in East India. END was defined as a worsening of ≥2 points on the National Institutes of Health Stroke Scale (NIHSS) within 7 days of admission. A score of 3-5 on the Modified Rankin Scale (mRS), a stroke recurrence event or death during hospital stay was considered poor hospital outcome. We performed univariate analysis using age, sex, body-mass index (BMI), hypertension, diabetes, NIHSS scores, stroke etiology, blood glucose and lipid parameters and plasma fibrinogen to develop a logistic regression model to establish the independent predictors of END and poor outcome. Results: Age (Odds Ratio (OR) 1.034 [95% CI 1.001-1.069], P =.046), NIHSS score at admission (OR 1.152 [95% CI 1.070-1.240], P <.001) and fibrinogen (OR 1.011 [95%CI 1.006-1.015], P <.001) were independent predictors of END in patients with acute ischemic stroke. Factors independently associated with poor outcome were NIHSS score at admission (OR 1.257 [95% CI 1.150-1.357], P <.001), fasting plasma glucose (OR 1.007 [95% CI 1.001-1.013], P =.020), and fibrinogen [OR 1.004 [95% CI 1.000-1.007], P =.038). Conclusion: The significant role of fibrinogen in determining neurological worsening and subsequent poor outcomes in patients with acute ischemic stroke may help in early prognostication and guided therapeutic interventions. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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