Chondroitin sulfate alleviates osteoporosis caused by calcium deficiency by regulating lipid metabolism.
The use of non-drug intervention for calcium deficiency has attracted attention in recent years. Although calcium carbonate is the preferred raw material for calcium supplementation, there are few reports on the mechanism of the combined action of chondroitin sulfate and calcium to alleviate osteopo...
| Published in: | Nutrition & Metabolism Vol. 20; no. 1; pp. 1 - 19 |
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| Main Authors: | , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
BioMed Central
2/8/2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161768161&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161768161 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 2/8/2023 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 161768161 161768161 161768161 10.1186/s12986-023-00726-3 161768161 ppf: 1 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Chondroitin sulfate alleviates osteoporosis caused by calcium deficiency by regulating lipid metabolism. aug: au: Liu, Tianshu Yu, Hai Wang, Shuai Li, Huimin Du, Xinyiran He, Xiaodong affil: Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, China sug: subj: Chondroitin Sulfates Therapeutic Use Osteoporosis Diet Therapy Osteoporosis Etiology Calcium Deficiency Dietary Supplementation Lipid Metabolism, Inborn Errors Models, Biological Microbiota Bone Density Correlational Studies Metabolomics Funding Source Gut Microbiota Calcium Carbonate Blood Chondroitin Sulfates RNA Sequence Analysis Fatty Acids, Volatile Osteoclasts Antioxidants Animal Studies Rats Feces Analysis ab: The use of non-drug intervention for calcium deficiency has attracted attention in recent years. Although calcium carbonate is the preferred raw material for calcium supplementation, there are few reports on the mechanism of the combined action of chondroitin sulfate and calcium to alleviate osteoporosis from the perspective of gut microbiota and metabolomics. In this study, a rat model of osteoporosis was established by feeding a low-calcium diet. The intestinal microbiota abundance, fecal and plasma metabolite expression levels of rats fed a basal diet, a low-calcium diet, a low-calcium diet plus calcium carbonate, and a low-calcium diet plus chondroitin sulfate were compared. The results showed that compared with the low calcium group, the calcium content and bone mineral density of femur were significantly increased in the calcium carbonate and chondroitin sulfate groups. 16 S rRNA sequencing and metabolomics analysis showed that chondroitin sulfate intervention could reduce short-chain fatty acid synthesis of intestinal flora, slow down inflammatory response, inhibit osteoclast differentiation, promote calcium absorption and antioxidant mechanism, and alleviate osteoporosis in low-calcium feeding rats. Correlation analysis showed that the selected intestinal flora was significantly correlated with metabolites enriched in feces and plasma. This study provides scientific evidence of the potential impact of chondroitin sulfate as a dietary supplement for patients with osteoporosis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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