Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice.
The multitude of obesogenic diets used in rodent studies can hardly be overviewed. Since standardization is missing and assuming that individual compositions provoke individual effects, the choice of quality, quantity and combination of diet ingredients seems to be crucial for the outcome and interp...
| Publicado en: | Nutrition & Metabolism Vol. 20; no. 1; pp. 1 - 16 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
BioMed Central
2/8/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161768162&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161768162 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17437075 1CYX jtl: Nutrition & Metabolism issn: 17437075 maglogo: N pubinfo: dt: 2/8/2023 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 161768162 161768162 161768162 10.1186/s12986-023-00729-0 161768162 ppf: 1 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Heterogeneous effects of individual high-fat diet compositions on phenotype, metabolic outcome, and hepatic proteome signature in BL/6 male mice. aug: au: Janoschek, Ruth Handwerk, Marion Hucklenbruch-Rother, Eva Schmitz, Lisa Bae-Gartz, Inga Kasper, Philipp Lackmann, Jan-Wilm Kretschmer, Tobias Vohlen, Christina Mesaros, Andrea Purrio, Martin Quaas, Alexander Dötsch, Jörg Appel, Sarah affil: Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937, Cologne, Germany sug: subj: Diet, Atherogenic Adverse Effects Dietary Fats Adverse Effects Dietary Sucrose Adverse Effects Phenotype Dietary Fats Metabolism Liver Metabolism Proteomics Dietary Sucrose Metabolism Obesity Metabolism Animal Studies Mice Adipose Tissue Metabolism Homeostasis Glucose Metabolism Adipocytes Pathology Blood Glucose Analysis Food Intake Fluid Intake Glucose Tolerance Test Tomography, X-Ray Computed Adipose Tissue Radiography Adipose Tissue Pathology Liver Pathology Enzyme-Linked Immunosorbent Assay Mass Spectrometry Descriptive Statistics One-Way Analysis of Variance Kruskal-Wallis Test ab: The multitude of obesogenic diets used in rodent studies can hardly be overviewed. Since standardization is missing and assuming that individual compositions provoke individual effects, the choice of quality, quantity and combination of diet ingredients seems to be crucial for the outcome and interpretation of obesity studies. Therefore, the present study was conducted to compare the individual effects of three commonly used obesogenic diets, mainly differing in sugar and fat content. Besides basic phenotypic and metabolic characterization, one main aspect was a comparative liver proteome analysis. As expected, the obtained results picture differentiated consequences mainly depending on fat source and/or fat- and sugar quantity. By confirming the general presumption that the choice of nutritional composition is a pivotal factor, the present findings demonstrate that a conscious selection is indispensable for obtaining reliable and sound results in obesity research. In conclusion, we strongly recommend a careful selection of the appropriate diet in advance of a new experiment, taking into account the specific research question. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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