A randomized controlled trial of a new intervention in early symptomatic syndromes eliciting neurodevelopmental clinical examinations: PR-ESSENCE.

The need for effective intervention programs for youth with neurodevelopmental problems (ESSENCE) and challenging behaviour is great. This study examines Problem Resolution in ESSENCE (PR-ESSENCE), a newly developed model in which children and parents develop mutual problem resolution strategies. Te...

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Publicado en:European Child & Adolescent Psychiatry Vol. 32; no. 1; pp. 63 - 75
Autores principales: Johnson, Mats, Gillberg, Carina, Vinsa, Ingrid, Fransson, Gunnar, Samuelsson, Lena, Jakobsson, Klara, Östlund, Sven, Fernell, Elisabeth, Gillberg, Christopher
Formato: research tables/charts randomized controlled trial Journal Article
Publicado: Springer Nature Jan2023
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jan2023
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      pub: Springer Nature
      place: New York, New York
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        atl: A randomized controlled trial of a new intervention in early symptomatic syndromes eliciting neurodevelopmental clinical examinations: PR-ESSENCE.
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        au:
          Johnson, Mats
          Gillberg, Carina
          Vinsa, Ingrid
          Fransson, Gunnar
          Samuelsson, Lena
          Jakobsson, Klara
          Östlund, Sven
          Fernell, Elisabeth
          Gillberg, Christopher
        affil: Gillberg Neuropsychiatry Centre, Sahlgrenska Academy, University of Gothenburg, Kungsgatan 12A, 411 19, Gothenburg, Sweden
      sug:
        subj:
          Neurodevelopment In Adolescence
          Neurologic Examination In Adolescence
          Mental Disorders Diagnosed in Childhood Therapy
          Psychotherapy Methods
          Adolescent Development
          Treatment Outcomes Evaluation
          Human
          Randomized Controlled Trials
          Adolescence
          Child Behavior Disorders
          Social Behavior Disorders
          Problem Solving
          Parent-Child Relations
          Child, Preschool
          Child
          Pretest-Posttest Design
          Scales
          Neuropsychological Tests
          Questionnaires
          Random Assignment
          Descriptive Statistics
          Funding Source
          Adolescent: 13-18 years
          Child, Preschool: 2-5 years
          Child: 6-12 years
      ab: The need for effective intervention programs for youth with neurodevelopmental problems (ESSENCE) and challenging behaviour is great. This study examines Problem Resolution in ESSENCE (PR-ESSENCE), a newly developed model in which children and parents develop mutual problem resolution strategies. Ten-week randomized controlled trial of PR-ESSENCE for children and adolescents aged 5–18 years, compared to treatment as usual. Outcomes were assessed at baseline and randomized period endpoint. Primary outcome was the Clinical Global Impression—Improvement scale (CGI-I) rated by blinded assessors. Secondary outcomes were rated by parents—SNAP-IV, Eyberg Child Behavior Inventory (ECBI), Relationship Problems Questionnaire, Family Burden of Illness Module, and children—Beck Youth Inventories (BYI). ClinicalTrials.gov identifier: NCT03780413. The study enrolled 108 participants (active n = 72; controls n = 36, randomized 2:1), of whom 95 completed the randomized period. No clinically significant group differences were found in baseline characteristics. More than half had autism and 80% had ADD or ADHD. Large treatment effects were seen on CGI-I (ITT analysis, Effect Size 1.48). Treatment responders, much/very much improved on CGI-I, were 51.4% in active group and 5.6% of controls. Effect sizes were medium to large in parent ratings on SNAP-IV (ODD and ADHD symptoms), ECBI (behaviour problems), and in BYI child self-ratings of disruptive behaviour. PR-ESSENCE treatment improved global symptoms and functioning (CGI-I), behaviour problems, ADHD and ODD symptoms, and disruptive behaviour. Treatment effects were at least equivalent to those in previous studies of well-established Parent Management Training and Collaborative Problem Solving programs.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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