Structural abnormalities in adolescents with conduct disorder and high versus low callous unemotional traits.
There may be distinct conduct disorder (CD) etiologies and neural morphologies in adolescents with high callous unemotional (CU) traits versus low CU traits. Here, we employed surface-based morphometry methods to investigate morphological differences in adolescents diagnosed with CD [42 with high CU...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 32; no. 1; pp. 193 - 204 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161768897&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161768897 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jan2023 vid: 32 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161768897 152942232 161768897 161768897 10.1007/s00787-021-01890-8 161768897 ppf: 193 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural abnormalities in adolescents with conduct disorder and high versus low callous unemotional traits. aug: au: Jiang, Yali Gao, Yidian Dong, Daifeng Sun, Xiaoqiang Situ, Weijun Yao, Shuqiao affil: Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, South China Normal University, Guangzhou, People's Republic of China sug: subj: Child Behavior Disorders Risk Factors Personality Disorders Complications Affective Disorders Complications Amygdala Abnormalities Neuroradiography Methods Abnormalities Complications Risk Assessment Magnetic Resonance Imaging Methods Human Male Female Funding Source Comparative Studies Adolescence Cerebral Cortex Abnormalities Parietal Lobe Abnormalities Hippocampus Abnormalities Abnormalities Diagnosis Aggression Risk Factors Neurobehavioral Manifestations China Descriptive Statistics Adolescent: 13-18 years Male Female ab: There may be distinct conduct disorder (CD) etiologies and neural morphologies in adolescents with high callous unemotional (CU) traits versus low CU traits. Here, we employed surface-based morphometry methods to investigate morphological differences in adolescents diagnosed with CD [42 with high CU traits (CD-HCU) and 40 with low CU traits (CD-LCU)] and healthy controls (HCs, N = 115) in China. Whole-brain analyses revealed significantly increased cortical surface area (SA) in the left inferior temporal cortex and the right precuneus, but decreased SA in the left superior temporal cortex in the CD-LCU group, compared with the HC group. There were no significant cortical SA differences between the CD-HCU and the HC groups. Compared to the CD-HCU group, the CD-LCU group had a greater cortical thickness (CT) in the left rostral middle frontal cortex. Region-of-interest analyses revealed significant group differences in the right hippocampus, with CD-HCU group having lower right hippocampal volumes than HCs. We did not detect significant group differences in the amygdalar volume, however, the right amygdalar volume was found to be a significant moderator of the correlation between CU traits and the proactive aggression in CD patients. The present results suggested that the manifestations of CD differ between those with high CU traits versus low CU traits, and underscore the importance of sample characteristics in understanding the neural substrates of CD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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