Investigating the role of contextual cues and interhemispheric inhibitory mechanisms in response-selective stopping: a TMS study.
Response-selective stopping requires cancellation of only one component of a multicomponent action. While research has investigated how delays to the continuing action components ("stopping interference") can be attenuated by way of contextual cues of the specific stopping demands ("foreknowledge"),...
| Publicado en: | Cognitive, Affective & Behavioral Neuroscience Vol. 23; no. 1; pp. 84 - 100 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161854216&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161854216 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Feb2023 vid: 23 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161854216 160257183 10.3758/s13415-022-01047-3 161854216 ppf: 84 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Investigating the role of contextual cues and interhemispheric inhibitory mechanisms in response-selective stopping: a TMS study. aug: au: Puri, Rohan St George, Rebecca J. Hinder, Mark R. affil: Sensorimotor Neuroscience and Ageing Research Group, Private Bag 30, School of Psychological Sciences, College of Health and Medicine, University of Tasmania, 7001, Hobart, TAS, Australia sug: ab: Response-selective stopping requires cancellation of only one component of a multicomponent action. While research has investigated how delays to the continuing action components ("stopping interference") can be attenuated by way of contextual cues of the specific stopping demands ("foreknowledge"), little is known of the underlying neural mechanisms. Twenty-seven, healthy, young adults undertook a multicomponent stop-signal task. For two thirds of trials, participants responded to an imperative (go) stimulus (IS) with simultaneous button presses using their left and right index fingers. For the remaining one third of trials, the IS was followed by a stop-signal requiring cancellation of only the left, or right, response. To manipulate foreknowledge of stopping demands, a cue preceded the IS that informed participants which hand might be required to stop (proactive) or provided no such information (reactive). Transcranial magnetic stimulation (TMS) assessed corticospinal excitability (CSE) as well as short- and long-interval interhemispheric inhibition (SIHI, LIHI) between the primary motor cortices. Proactive cues reduced, but did not eliminate, stopping interference relative to the reactive condition. Relative to TMS measures at cue onset, decreases in CSE (both hands and both cue conditions) and LIHI (both hands, proactive condition only) were observed during movement preparation. During movement cancellation, LIHI reduction in the continuing hand was greater than that in the stopping hand and greater than LIHI reductions in both hands during execution of multicomponent responses. Our results indicate that foreknowledge attenuates stopping interference and provide evidence for a novel role of LIHI, mediated via prefrontal regions, in facilitating continuing action components. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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