Metabotropic group II glutamate receptors mediate cue-triggered increases in reward-seeking behaviour.
Rationale: Reward-associated cues can invigorate reward-seeking actions via Pavlovian-to-instrumental transfer (PIT). Glutamatergic neurotransmission mediates the appetitive effects of reward-associated cues. We characterized the expression of PIT and its mediation by metabotropic group II glutamate...
| Published in: | Psychopharmacology Vol. 240; no. 3; pp. 515 - 530 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Mar2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161884561&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161884561 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Mar2023 vid: 240 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161884561 10.1007/s00213-022-06101-z 161884561 ppf: 515 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Metabotropic group II glutamate receptors mediate cue-triggered increases in reward-seeking behaviour. aug: au: Garceau, Caroline Marsault, Justine Robinson, Mike J. F. Samaha, Anne-Noël affil: Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-Ville, H3T 1J4, Montréal, QC, Canada sug: ab: Rationale: Reward-associated cues can invigorate reward-seeking actions via Pavlovian-to-instrumental transfer (PIT). Glutamatergic neurotransmission mediates the appetitive effects of reward-associated cues. We characterized the expression of PIT and its mediation by metabotropic group II glutamate (mGlu2/3) receptor activity in female and male rats. Objectives: Across the sexes, we used PIT procedures to determine (i) cue-triggered increases in instrumental responding for water reward (experiment 1) and (ii) the respective influences of the mGlu2/3 receptor agonist LY379268 and thirst satiation on this effect (experiment 2). Methods: Water-restricted female and male Sprague–Dawley rats learned to lever press for water. Separately, they learned that one of two auditory stimuli predicts free water (CS + vs CS −). On PIT test days, the CS + and CS − were presented independent of instrumental responding, and we measured effects on lever pressing under extinction (no water). In experiment 1, we characterized PIT across the sexes. In experiment 2, we measured PIT after systemic LY379268 administration (0, 0.3 and 1 mg/kg) and thirst satiation, respectively. Results: Female and male rats showed similar PIT, with CS + but not CS − presentations potentiating water-seeking behaviour. LY379268 (1 mg/kg) attenuated CS + evoked increases in both water-associated lever pressing and conditioned approach to the water port. Thirst satiation attenuated both water-seeking and CS + evoked conditioned approach behaviour. Conclusions: The sexes show similar cue-triggered increases in reward seeking, and thirst satiation suppresses both water-seeking and cue-triggered anticipation of water reward. Finally, across the sexes, mGlu2/3 receptor activity mediates cue-triggered increases in reward seeking. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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