Tumor lesion detection in patients with cervical cancer by indocyanine green near-infrared imaging.
Purpose: To investigate the feasibility and accuracy of near-infrared fluorescence (NIRF) imaging for detecting the extent of tumor invasion in cervical cancer using indocyanine green (ICG). Methods: We enrolled 51 patients who were diagnosed with cervical cancer with FIGO stage IB1-IIA2 disease. Pa...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 50; no. 4; pp. 1252 - 1262 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161898976&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161898976 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Mar2023 vid: 50 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161898976 160616202 10.1007/s00259-022-06030-1 161898976 ppf: 1252 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Tumor lesion detection in patients with cervical cancer by indocyanine green near-infrared imaging. aug: au: Li, Pengfei Liu, Jiaqi He, Kunshan Gong, Shipeng Chi, Chongwei Liu, Pan Su, Guidong Li, Weili Duan, Hui Liu, Ping Tian, Jie Chen, Chunlin affil: Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue, 510515, Guangzhou, China sug: ab: Purpose: To investigate the feasibility and accuracy of near-infrared fluorescence (NIRF) imaging for detecting the extent of tumor invasion in cervical cancer using indocyanine green (ICG). Methods: We enrolled 51 patients who were diagnosed with cervical cancer with FIGO stage IB1-IIA2 disease. Patients were administered indocyanine green (ICG) at a dose of 5 mg/kg 24 h prior to surgery. A customized near-infrared fluorescence (NIRF) imaging system was used to identify the extent of tumor invasion when radical hysterectomy specimens were harvested. The relationship between tumor fluorescence intensity and clinicopathological characteristics was analyzed. Results: Of the 51 enrolled patients, 3 patients did not have residual tumors after cervical conization, and tumor lesions were identified by NIRF imaging in all the remaining 48 patients. The results of NIRF imaging were in agreement with the postoperative pathological findings in 95.8% of the patients with stromal invasion, 100% of those with surgical margin invasion, 100% of those with parametrial tumor involvement, and 100% of patients with uterine corpus invasion. The mean signal-to-background ratio (SBR) of the cervical tumors was 2.91 ± 1.64, and the SBR was independent of clinicopathological characteristics. Fluorescence microscopy confirmed that ICG fluorescence was present in the tumor nests. Conclusions: NIRF imaging enables objective, accurate, and safe identification of tumor invasion during cervical cancer surgery. Clinical trial registration: ClinicalTrials.gov NCT04224467. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|