A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues.
Alcohol misuse contributes to the dysregulation of immune responses and multiorgan dysfunction across various tissues, which are associated with higher risk of morbidity and mortality in people with alcohol use disorders. Organ‐specific immune cells, including microglia in the brain, alveolar macrop...
| Publicado en: | Alcohol, Clinical & Experimental Research Vol. 47; no. 1; pp. 36 - 45 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161985248&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161985248 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 29937175 NACB jtl: Alcohol, Clinical & Experimental Research issn: 29937175 maglogo: N pubinfo: dt: Jan2023 vid: 47 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 161985248 160472401 161985248 169935265 161985248 10.1111/acer.14979 161985248 ppf: 36 ppct: 9 formats: tig: atl: A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues. aug: au: Crotty, Kathryn Anton, Paige Coleman, Leon G. Morris, Niya L. Lewis, Sloan A. Samuelson, Derrick R. McMahan, Rachel H. Hartmann, Phillipp Kim, Adam Ratna, Anuradha Mandrekar, Pranoti Wyatt, Todd A. Choudhry, Mashkoor A. Kovacs, Elizabeth J. McCullough, Rebecca Yeligar, Samantha M. affil: Department of Medicine, Emory University, Atlanta Georgia,, USA sug: subj: Alcoholism Risk Factors Immunity Multiple Organ Dysfunction Syndrome Risk Assessment Liver Physiology Lung Physiology Macrophages Metabolism Brain Physiology Inflammation Molecular Structure Homeostasis Binge Drinking ab: Alcohol misuse contributes to the dysregulation of immune responses and multiorgan dysfunction across various tissues, which are associated with higher risk of morbidity and mortality in people with alcohol use disorders. Organ‐specific immune cells, including microglia in the brain, alveolar macrophages in the lungs, and Kupffer cells in the liver, play vital functions in host immune defense through tissue repair and maintenance of homeostasis. However, binge drinking and chronic alcohol misuse impair these immune cells' abilities to regulate inflammatory signaling and metabolism, thus contributing to multiorgan dysfunction. Further complicating these delicate systems, immune cell dysfunction associated with alcohol misuse is exacerbated by aging and gut barrier leakage. This critical review describes recent advances in elucidating the potential mechanisms by which alcohol misuse leads to derangements in host immunity and highlights current gaps in knowledge that may be the focus of future investigations. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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