Whole fresh fruit intake and risk of incident diabetes in different glycemic stages: a nationwide prospective cohort investigation.
Purpose: Fruit intake is beneficial to several chronic diseases, but controversial in diabetes. We aimed to investigate prospectively the associations of whole fresh fruit intake with risk of incident type 2 diabetes (T2D) in subjects with different glucose regulation capacities. Methods: The presen...
| Published in: | European Journal of Nutrition Vol. 62; no. 2; pp. 771 - 783 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Mar2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161991395&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161991395 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2023 vid: 62 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161991395 159757401 161991395 161991395 10.1007/s00394-022-02998-6 161991395 ppf: 771 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Whole fresh fruit intake and risk of incident diabetes in different glycemic stages: a nationwide prospective cohort investigation. aug: au: Li, Li Yang, Hai-Yan Ma, Yan Liang, Xing-Huan Xu, Min Zhang, Jie Huang, Zhen-Xing Meng, Li-Heng Zhou, Jia Xian, Jing Suo, Ying-Jun Huang, Song Cai, Jin-Wei Meng, Bi-Hui Zhao, Zhi-Yun Lu, Jie-Li Xu, Yu Wang, Tian-Ge Li, Mian Chen, Yu-Hong affil: Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, No. 6 of Shuangyong Road, 530021, Nanning, Guangxi, China sug: subj: Diabetes Mellitus, Type 2 Epidemiology Diabetes Mellitus, Type 2 Risk Factors Fruit Food Intake Prediabetic State Glucose Metabolism Risk Assessment Human Male Female Adult China Prospective Studies Questionnaires Glycated Hemoglobin Blood Fasting Blood Glucose Cox Proportional Hazards Model Confidence Intervals Dose-Response Relationship Descriptive Statistics Funding Source Adult: 19-44 years Male Female ab: Purpose: Fruit intake is beneficial to several chronic diseases, but controversial in diabetes. We aimed to investigate prospectively the associations of whole fresh fruit intake with risk of incident type 2 diabetes (T2D) in subjects with different glucose regulation capacities. Methods: The present study included 79,922 non-diabetic participants aged ≥ 40 years from an ongoing nationwide prospective cohort in China. Baseline fruit intake information was collected by a validated food frequency questionnaire. Plasma HbA1c, fasting and 2 h post-loading glucose levels were measured at both baseline and follow-up examinations. Cox proportional hazards models were used to calculate hazard ratio (HR) and 95% confidence intervals (CI) for incident diabetes among participants with normal glucose tolerance (NGT) and prediabetes, after adjusted for multiple confounders. Restricted cubic spline analysis was applied for dose–response relation. Results: During a median 3.8-year follow-up, 5886 (7.36%) participants developed diabetes. Overall, we identified a linear and dose-dependent inverse association between dietary whole fresh fruit intake and risk of incident T2D. Each 100 g/d higher fruit intake was associated with 2.8% lower risk of diabetes (HR 0.972, 95%CI [0.949–0.996], P = 0.0217), majorly benefiting NGT subjects with 15.2% lower risk (HR 0.848, 95%CI [0.766–0.940], P = 0.0017), while not significant in prediabetes (HR 0.981, 95%CI 0.957–4.005, P = 0.1268). Similarly, the inverse association was present in normoglycemia individuals with a 48.6% lower risk of diabetes when consuming fruits > 7 times/week comparing to those < 1 time/week (HR 0.514, 95% CI [0.368–0.948]), but not in prediabetes (HR 0.883, 95% CI [0.762–1.023]). Conclusion: These findings suggest that higher frequency and amount of fresh fruit intake may protect against incident T2D, especially in NGT, but not in prediabetes, highlighting the dietary recommendation of higher fresh fruit consumption to prevent T2D in normoglycemia population. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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