The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials
Purpose: Probiotics or synbiotics consumption have been suggested to reduce the risk of cardiovascular disease (CVD) through a decline in inflammation and oxidative stress, however, the results from studies are conflicting. This study filled this knowledge gap by evaluating randomized controlled tri...
| Published in: | European Journal of Nutrition Vol. 62; no. 2; pp. 543 - 562 |
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| Main Authors: | , , , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Springer Nature
Mar2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161991400&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161991400 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2023 vid: 62 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161991400 159651499 161991400 161991400 10.1007/s00394-022-03012-9 161991400 ppf: 543 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials aug: au: Naseri, Kaveh Saadati, Saeede Ghaemi, Farahnaz Ashtary-Larky, Damoon Asbaghi, Omid Sadeghi, Amir Afrisham, Reza de Courten, Barbora affil: Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran sug: subj: Probiotics Pharmacodynamics Dietary Supplements Adipokines Inflammation Prevention and Control Oxidative Stress Prediabetic State Metabolism Diabetes Mellitus, Type 2 Metabolism Biological Markers Cardiometabolic Risk Factors Prevention and Control Human Male Female Middle Age Aged Systematic Review Meta Analysis PubMed Medline Cochrane Library Confidence Intervals C-Reactive Protein Tumor Necrosis Factor Malondialdehyde Glutathione Antioxidants Nitric Oxide Interleukins Synbiotics Pharmacodynamics Adiponectin Funding Source Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: Probiotics or synbiotics consumption have been suggested to reduce the risk of cardiovascular disease (CVD) through a decline in inflammation and oxidative stress, however, the results from studies are conflicting. This study filled this knowledge gap by evaluating randomized controlled trials (RCTs) investigating probiotics or synbiotics intake on adipokines, inflammation, and oxidative stress in patients with prediabetes and type-2 diabetes mellitus (T2DM). Methods: We systematically did search up to March 2022 in PubMed/Medline, Scopus, ISI Web of Science, and Cochrane library. A random-effect model was applied to estimate the weighted mean difference (WMD) and 95% confidence interval (95% CI) for each outcome. Results: A total of 32 RCTs were included in the meta-analysis. This intervention led to a significant decrease in levels of C-reactive protein (CRP) (WMD − 0.62 mg/l; 95% CI − 0.80, − 0.44; p < 0.001), tumor necrosis factor-α (TNF-α) (WMD − 0.27 pg/ml; 95% CI − 0.44, − 0.10; p = 0.002) and malondialdehyde (MDA) (WMD − 0.51 µmol/l; 95% CI − 0.73, − 0.30; p < 0.001), and also a significant increase in levels of glutathione (GSH) (WMD 69.80 µmol/l; 95% CI 33.65, 105.95; p < 0.001), total antioxidant capacity (TAC) (WMD 73.59 mmol/l; 95% CI 33.24, 113.95; p < 0.001) and nitric oxide (NO) (WMD 7.49 µmol/l; 95% CI 3.12, 11.86; p = 0.001), without significant alterations in interleukin-6 (IL-6) and adipokines levels. Conclusion: A consumption of probiotics or synbiotics could be a useful intervention to improve cardiometabolic outcomes through a reduced inflammation and oxidative stress in patients with prediabetes and T2DM. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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