Effect of chia flour associated with high fat diet on intestinal health in female ovariectomized Wistar rats.
Purpose: The present study aimed to evaluate the effect of chia flour associated with a high fat diet on intestinal health in female ovariectomized Wistar rats. Methods: The study was conducted with 32 adult female ovariectomized Wistar rats, which were separated into four groups: standard diet (ST)...
| Publicado en: | European Journal of Nutrition Vol. 62; no. 2; pp. 905 - 920 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161991428&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161991428 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2023 vid: 62 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161991428 160015668 161991428 161991428 10.1007/s00394-022-03043-2 161991428 ppf: 905 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effect of chia flour associated with high fat diet on intestinal health in female ovariectomized Wistar rats. aug: au: Mishima, Marcella Duarte Villas da Silva, Bárbara Pereira Gomes, Mariana Juste Contin Toledo, Renata Celi Lopes Pereira, Carlos Eduardo Real Costa, Neuza Maria Brunoro Martino, Hércia Stampini Duarte affil: Department of Nutrition and Health, Federal University of Viçosa/UFV, 36570-900, Viçosa, MG, Brazil sug: subj: Salvia Hispanica Pharmacodynamics Plant Extracts Pharmacodynamics Plants, Medicinal Intestinal Diseases Drug Therapy Dietary Fats Animal Studies Rats Descriptive Statistics One-Way Analysis of Variance Gut Microbiota Evaluation Peptide Hydrolases Metabolism Dietary Sucrose Metabolism Fatty Acids Metabolism Funding Source ab: Purpose: The present study aimed to evaluate the effect of chia flour associated with a high fat diet on intestinal health in female ovariectomized Wistar rats. Methods: The study was conducted with 32 adult female ovariectomized Wistar rats, which were separated into four groups: standard diet (ST), standard diet with chia (STC), high fat diet (HF) and high fat diet with chia (HFC) for 18 weeks. Cecum content pH, short chain fatty acid content, brush border membrane functionality and morphology and the gut microbiota were evaluated. Results: This study demonstrated that the consumption of chia flour increased the production of acetic and butyric acids, the longitudinal and circular muscle layers and crypt thickness. It also improved the expression of aminopeptidase (AP) and sucrose-isomaltase (SI) and decreased the cecum content pH. Further, the consumption of chia improved richness and decreased diversity of the microbiota. Operational Taxonomic Units (OTUs) clustering indicated difference between the ST and STC groups. In the linear discriminant analysis effect size (LEfSe) analysis, the Bacteroides genus and members of the Muribaculaceae and Lachnospiraceae families were enriched in the STC treatment group. The STC group demonstrated the enrichment of Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways related to peptidoglycan and coenzyme A biosynthesis. Conclusion: Our results suggest that chia flour, which is rich in dietary fiber and phenolic compounds, presented potential properties to improve intestinal health. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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