The effect of tetrahydrocannabinol:cannabidiol oromucosal spray on cognition: a systematic review.
Purpose: Previous studies have shown that tetrahydrocannabinol (THC), the main psychoactive component of cannabis, can impair cognitive abilities. There is also some evidence that cannabidiol (CBD), the most abundant non-intoxicating constituent of cannabis, can attenuate these effects. The purpose...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 79; no. 3; pp. 371 - 382 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161991847&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161991847 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Mar2023 vid: 79 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161991847 161503409 161991847 161991847 10.1007/s00228-023-03454-y 161991847 ppf: 371 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The effect of tetrahydrocannabinol:cannabidiol oromucosal spray on cognition: a systematic review. aug: au: Motaghi, Ehsan Ghasemi-Pirbaluti, Masoumeh Rashidi, Mohsen Alasvand, Masoud Di Ciano, Patricia Bozorgi, Hooman affil: Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran sug: subj: Hydrocarbons Pharmacodynamics Cannabidiol Pharmacodynamics Dosage Forms Administration, Oral Cognition Treatment Outcomes Human Systematic Review Funding Source Psychotropic Drugs Drug Efficacy Multiple Sclerosis Cannabis ab: Purpose: Previous studies have shown that tetrahydrocannabinol (THC), the main psychoactive component of cannabis, can impair cognitive abilities. There is also some evidence that cannabidiol (CBD), the most abundant non-intoxicating constituent of cannabis, can attenuate these effects. The purpose of this study was to investigate the effects of THC:CBD oromucosal spray (with equal parts THC and CBD) on cognition compared with control conditions in human studies. Methods: A systematic literature search was performed on four major bibliographic databases. Studies were included in the present review if they evaluated the cognitive effects of THC:CBD oromucosal spray compared with a control condition. Results: Ten studies were identified (7 on patients with multiple sclerosis, 1 on those with Huntington, and 2 on healthy volunteers) with 510 participants in total. There was considerable heterogeneity among the studies in terms of dose and duration of administration. All studies have used an equal or nearly equal dose of THC and CBD. Conclusions: Although the results across studies were somewhat inconsistent, most evidence revealed that there is no significant difference between THC:CBD oromucosal spray and control treatments in terms of cognitive outcomes. However, more trials are needed with longer follow-up periods, and dose considerations, particularly comparing lower and higher doses of the spray. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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