Cryptococcal Antigenemia in Advanced Human Immunodeficiency Virus Disease: Pathophysiology, Epidemiology, and Clinical Implications.
Cryptococcal antigen (CrAg) is detectable in blood prior to the onset of symptomatic cryptococcal meningitis (CM), a leading cause of death among people with advanced human immunodeficiency virus (HIV) disease globally. Highly sensitive assays can detect CrAg in blood, and screening people with HIV...
| Publicado en: | Clinical Infectious Diseases Vol. 76; no. 4; pp. 764 - 771 |
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| Autores principales: | , , , , |
| Formato: | algorithm pictorial review tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
2/15/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162026159&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162026159 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10584838 46X jtl: Clinical Infectious Diseases issn: 10584838 maglogo: N pubinfo: dt: 2/15/2023 vid: 76 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 162026159 162026159 162026159 10.1093/cid/ciac675 162026159 ppf: 764 ppct: 7 formats: tig: atl: Cryptococcal Antigenemia in Advanced Human Immunodeficiency Virus Disease: Pathophysiology, Epidemiology, and Clinical Implications. aug: au: Wake, Rachel M Molloy, Síle F Jarvis, Joseph N Harrison, Thomas S Govender, Nelesh P affil: Institute for Infection and Immunity, St George's University of London , London , United Kingdom sug: subj: HIV Infections Epidemiology HIV Infections Complications Cryptococcus Analysis Meningitis, Cryptococcal Physiopathology Meningitis, Cryptococcal Risk Factors Meningitis, Cryptococcal Drug Therapy Antibiotics, Antifungal Therapeutic Use Risk Assessment Antigens, Viral Blood CD4 Lymphocyte Count Cerebrospinal Fluid Analysis Meningitis, Cryptococcal Mortality Meningitis, Cryptococcal Etiology Diagnostic Services Health Screening ab: Cryptococcal antigen (CrAg) is detectable in blood prior to the onset of symptomatic cryptococcal meningitis (CM), a leading cause of death among people with advanced human immunodeficiency virus (HIV) disease globally. Highly sensitive assays can detect CrAg in blood, and screening people with HIV with low CD4 counts, followed by preemptive antifungal treatment, is recommended and widely implemented as part of a global strategy to prevent CM and end cryptococcal-related deaths. Cryptococcal antigenemia encompasses a spectrum of conditions from preclinical asymptomatic infection (cerebrospinal fluid [CSF] CrAg-negative) through subclinical (CSF CrAg-positive without overt meningism) to clinical symptomatic cryptococcal disease, usually manifesting as CM. In this review, we summarize current understanding of the pathophysiology, risk factors for, and clinical implications of cryptococcal antigenemia within this spectrum. We also provide an update on global prevalence, recommended screening and treatment strategies, and future considerations for improving outcomes among patients with cryptococcal antigenemia. pubtype: Academic Journal doctype: algorithm pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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