Correction of Retinal Nerve Fiber Layer Thickness Measurement on Spectral-Domain Optical Coherence Tomographic Images Using U-net Architecture.
Purpose: In this study, an algorithm based on deep learning was presented to reduce the retinal nerve fiber layer (RNFL) segmentation errors in spectral domain optical coherence tomography (SD-OCT) scans using ophthalmologists' manual segmentation as a reference standard. Methods: In this study, we...
| Published in: | Journal of Ophthalmic & Vision Research Vol. 18; no. 1; pp. 41 - 51 |
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| Main Authors: | , , |
| Format: | equations & formulas pictorial research tables/charts Journal Article |
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Knowledge E DMCC
Jan-Mar2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162044639&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162044639 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082010 AY5S jtl: Journal of Ophthalmic & Vision Research issn: 20082010 maglogo: N pubinfo: dt: Jan-Mar2023 vid: 18 iid: 1 pid: 35682 pub: Knowledge E DMCC artinfo: ui: 162044639 162044639 162044639 10.18502/jovr.v18i1.12724 162044639 ppf: 41 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Correction of Retinal Nerve Fiber Layer Thickness Measurement on Spectral-Domain Optical Coherence Tomographic Images Using U-net Architecture. aug: au: Razaghi, Ghazale Fard, Masoud Aghsaei Hejazi, Marjaneh affil: Medical Physics and Biomedical Engineering Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran sug: subj: Nerve Fibers Anatomy and Histology Optic Nerve Diseases Diagnosis Tomography, Optical Coherence Retinal Diseases Therapy Neural Networks (Computer) Image Processing, Computer Assisted Algorithms Deep Learning Ophthalmologists Artifacts Correlation Coefficient Prediction Models Human Male Female Young Adult Adult Middle Age Aged Aged, 80 and Over Data Analysis Software Descriptive Statistics Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: In this study, an algorithm based on deep learning was presented to reduce the retinal nerve fiber layer (RNFL) segmentation errors in spectral domain optical coherence tomography (SD-OCT) scans using ophthalmologists' manual segmentation as a reference standard. Methods: In this study, we developed an image segmentation network based on deep learning to automatically identify the RNFL thickness from B-scans obtained with SD-OCT. The scans were collected from Farabi Eye Hospital (500 B-scans were used for training, while 50 were used for testing). To remove the speckle noise from the images, preprocessing was applied before training, and postprocessing was performed to fill any discontinuities that might exist. Afterward, output masks were analyzed for their average thickness. Finally, the calculation of mean absolute error between predicted and ground truth RNFL thickness was performed. Results: Based on the testing database, SD-OCT segmentation had an average dice similarity coefficient of 0.91, and thickness estimation had a mean absolute error of 2.23 ± 2.1 |Jm. As compared to conventional OCT software algorithms, deep learning predictions were better correlated with the best available estimate during the test period (r² = 0.99 vs r² = 0.88, respectively; P < 0.001). Conclusion: Our experimental results demonstrate effective and precise segmentation of the RNFL layer with the coefficient of 0.91 and reliable thickness prediction with MAE 2.23 ± 2.1 jm in SD-OCT B-scans. Performance is comparable with human annotation of the RNFL layer and other algorithms according to the correlation coefficient of 0.99 and 0.88, respectively, while artifacts and errors are evident. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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