Cortical hemodynamic response during cognitive Stroop test in acute stroke patients assessed by fNIRS.
BACKGROUND: Following acute ischemic stroke (AIS) many patients experience cognitive impairment which interferes neurorehabilitation. Understanding and monitoring pathophysiologic processes behind cognitive symptoms requires accessible methods during testing and training. Functional near-infrared sp...
| Publicado en: | NeuroRehabilitation Vol. 52; no. 2; pp. 199 - 218 |
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| Autores principales: | , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162119942&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162119942 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10538135 3RE jtl: NeuroRehabilitation issn: 10538135 maglogo: N pubinfo: dt: 2023 vid: 52 iid: 2 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 162119942 161224567 162119942 162119942 10.3233/NRE-220171 162119942 ppf: 199 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Cortical hemodynamic response during cognitive Stroop test in acute stroke patients assessed by fNIRS. aug: au: Heiberg, Adam Vittrup Simonsen, Sofie Amalie Schytz, Henrik Winther Iversen, Helle Klingenberg affil: Clinical Stroke Research Unit, Department of Neurology, Copenhagen University Hospital – Rigshospitalet, Glostrup, Denmark sug: subj: Prefrontal Cortex Physiopathology Hemodynamics Evaluation Cognition Evaluation Ischemic Stroke Physiopathology Clinical Assessment Tools Utilization Spectroscopy, Near-Infrared Utilization Biological Markers Analysis Ischemic Stroke Rehabilitation Executive Function Evaluation Human Prospective Studies Nonexperimental Studies Male Female Middle Age Aged Stroke Patients Funding Source Severity of Illness Matched Case Control Task Performance and Analysis Cognition Disorders Risk Factors Ischemic Stroke Complications Middle Aged: 45-64 years Aged: 65+ years Male Female ab: BACKGROUND: Following acute ischemic stroke (AIS) many patients experience cognitive impairment which interferes neurorehabilitation. Understanding and monitoring pathophysiologic processes behind cognitive symptoms requires accessible methods during testing and training. Functional near-infrared spectroscopy (fNIRS) can assess activational hemodynamic responses in the prefrontal cortex (PFC) and feasibly be used as a biomarker to support stroke rehabilitation. OBJECTIVE: Exploring the feasibility of fNIRS as a biomarker during the Stroop Color and Word Test (SCWT) assessing executive function in AIS patients. METHODS: Observational study of 21 patients with mild to moderate AIS and 22 healthy age- and sex-matched controls (HC) examined with fNIRS of PFC during the SCWT. Hemodynamic responses were analyzed with general linear modeling. RESULTS: The SCWT was performed worse by AIS patients than HC. Neither patients nor HC showed PFC activation, but an inverse activational pattern primarily in superolateral and superomedial PFC significantly lower in AIS. Hemodynamic responses were incoherent to test difficulty and performance. No other group differences or lateralization were found. CONCLUSIONS: AIS patients had impaired executive function assessed by the SCWT, while both groups showed an inverse hemodynamic response significantly larger in HC. Investigations assessing the physiology behind inverse hemodynamic responses are warranted before deeming clinical implementation reasonable. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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