Late-life depression and multimorbidity trajectories: the role of symptom complexity and severity.
Introduction as late-life depression is associated with poor somatic health, we aimed to investigate the role of depression severity and symptom phenotypes in the progression of somatic multimorbidity. Methods we analysed data from 3,042 dementia-free individuals (60+) participating in the populatio...
| Published in: | Age & Ageing Vol. 52; no. 2; pp. 1 - 10 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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Oxford University Press / USA
Feb2023
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=162161653&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 162161653 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Feb2023 vid: 52 iid: 2 pid: 622 pub: Oxford University Press / USA artinfo: ui: 162161653 10.1093/ageing/afac315 ppf: 1 ppct: 9 formats: tig: atl: Late-life depression and multimorbidity trajectories: the role of symptom complexity and severity. aug: au: Triolo, Federico Sjöberg, Linnea Calderón-Larrañaga, Amaia Murri, Martino Belvederi Vetrano, Davide Liborio Fratiglioni, Laura Dekhtyar, Serhiy affil: Aging Research Center , Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University , Stockholm , Sweden Stockholm Gerontology Research Center , Stockholm , Sweden Institute of Psychiatry , Department of Neuroscience and Rehabilitation, University of Ferrara , Ferrara , Italy su: Diagnosis of mental depression Mental depression Sociodemographic factors Old age Confidence intervals Regression analysis Severity of illness index Research funding Descriptive statistics Psychomotor disorders Data analysis software Comorbidity Phenotypes Longitudinal method sug: subj: Diagnosis of mental depression Mental depression Sociodemographic factors Old age Confidence intervals Regression analysis Severity of illness index Research funding Descriptive statistics Psychomotor disorders Data analysis software Comorbidity Phenotypes Longitudinal method keyword: comorbidity depression epidemiology longitudinal older people psychosomatic symptom network comorbidity depression epidemiology longitudinal older people psychosomatic symptom network ab: Introduction as late-life depression is associated with poor somatic health, we aimed to investigate the role of depression severity and symptom phenotypes in the progression of somatic multimorbidity. Methods we analysed data from 3,042 dementia-free individuals (60+) participating in the population-based Swedish National Study on Aging and Care in Kungsholmen. Using the baseline clinical assessment of 21 depressive symptoms from the Comprehensive Psychopathological Rating Scale, we: (i) diagnosed major, minor (in accordance with DSM-IV-TR) and subsyndromal depression; (ii) extracted symptom phenotypes by applying exploratory network graph analysis. Somatic multimorbidity was measured as the number of co-occurring chronic diseases over a 15-year follow-up. Linear mixed models were used to explore somatic multimorbidity trajectories in relation to baseline depression diagnoses and symptom phenotypes, while accounting for sociodemographic and behavioural factors. Results in multi-adjusted models, relative to individuals without depression, those with major (β per year: 0.33, 95% confidence interval [CI]: 0.06–0.61) and subsyndromal depression (β per year: 0.21, 95%CI: 0.12–0.30) experienced an accelerated rate of somatic multimorbidity accumulation, whereas those with minor depression did not. We identified affective, anxiety, cognitive, and psychomotor symptom phenotypes from the network analysis. When modelled separately, an increase in symptom score for each phenotype was associated with faster multimorbidity accumulation, although only the cognitive phenotype retained its association in a mutually adjusted model (β per year: 0.07, 95%CI: 0.03–0.10). Conclusions late-life major and subsyndromal depression are associated with accelerated somatic multimorbidity. Depressive symptoms characterised by a cognitive phenotype are linked to somatic health change in old age. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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