Non-Expert Markings of Active Chronic Graft-Versus-Host Disease Photographs: Optimal Metrics of Training Effects.

Lack of reliable measures of cutaneous chronic graft-versus-host disease (cGVHD) remains a significant challenge. Non-expert assistance in marking photographs of active disease could aid the development of automated segmentation algorithms, but validated metrics to evaluate training effects are lack...

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Publicado en:Journal of Digital Imaging Vol. 36; no. 1; pp. 373 - 379
Autores principales: Parks, Kelsey, Liu, Xiaoqi, Reasat, Tahsin, Khera, Zain, Baker, Laura X., Chen, Heidi, Dawant, Benoit M., Saknite, Inga, Tkaczyk, Eric R.
Formato: pictorial research tables/charts Journal Article
Publicado: Springer Nature Feb2023
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
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        10.1007/s10278-022-00730-8
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        atl: Non-Expert Markings of Active Chronic Graft-Versus-Host Disease Photographs: Optimal Metrics of Training Effects.
      aug:
        au:
          Parks, Kelsey
          Liu, Xiaoqi
          Reasat, Tahsin
          Khera, Zain
          Baker, Laura X.
          Chen, Heidi
          Dawant, Benoit M.
          Saknite, Inga
          Tkaczyk, Eric R.
        affil: Dermatology Service and Research Service, Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA
      sug:
        subj:
          Chronic Disease
          Graft Versus Host Disease
          Photography
          Skin Diseases
          Image Interpretation, Computer Assisted
          Human
          Sensitivity and Specificity
          Descriptive Statistics
          Data Analysis Software
          Validation Studies
          Outcome Assessment
          Clinical Competence
          Skill Acquisition
      ab: Lack of reliable measures of cutaneous chronic graft-versus-host disease (cGVHD) remains a significant challenge. Non-expert assistance in marking photographs of active disease could aid the development of automated segmentation algorithms, but validated metrics to evaluate training effects are lacking. We studied absolute and relative error of marked body surface area (BSA), redness, and the Dice index as potential metrics of non-expert improvement. Three non-experts underwent an extensive training program led by a board-certified dermatologist to mark cGVHD in photographs. At the end of the 4-month training, the dermatologist confirmed that each trainee had learned to accurately mark cGVHD. The trainees' inter- and intra-rater intraclass correlation coefficient estimates were "substantial" to "almost perfect" for both BSA and total redness. For fifteen 3D photos of patients with cGVHD, the trainees' median absolute (relative) BSA error compared to expert marking dropped from 20 cm2 (29%) pre-training to 14 cm2 (24%) post-training. Total redness error decreased from 122 a*·cm2 (26%) to 95 a*·cm2 (21%). By contrast, median Dice index did not reflect improvement (0.76 to 0.75). Both absolute and relative BSA and redness errors similarly and stably reflected improvements from this training program, which the Dice index failed to capture.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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