Antibiotic‐loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: A meta‐analysis.
In recent years, local antibiotic‐loaded bone substitutes (ALBS) have been used increasingly in the treatment of diabetic foot infection (DFI). The meta‐analysis aimed to analyse the efficacy of ALBS on patients with moderate to severe DFI (with or without osteomyelitis). With an appropriate search...
| Publicado en: | Wound Repair & Regeneration Vol. 31; no. 2; pp. 205 - 227 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Mar/Apr2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162397484&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162397484 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10671927 DPV jtl: Wound Repair & Regeneration issn: 10671927 maglogo: Y pubinfo: dt: Mar/Apr2023 vid: 31 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 162397484 161169953 162397484 162397484 10.1111/wrr.13061 162397484 ppf: 205 ppct: 22 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Antibiotic‐loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: A meta‐analysis. aug: au: Lin, Xinyi Wu, Yan Huang, Hong Peng, Ruihan Huang, FuHua Hong, Lvrong Chen, WenZhuan affil: Guangzhou Women and Children's Medical Center, Guangzhou Guangdong Province,, China sug: subj: Severity of Illness Diabetic Foot Therapy Wound Infection Therapy Antibiotics Therapeutic Use Bone Substitutes Therapeutic Use Wound Care Methods Treatment Outcomes Evaluation Osteomyelitis Therapy Human Systematic Review Meta Analysis Length of Stay Evaluation Recurrence Prevention and Control Confidence Intervals Descriptive Statistics Relative Risk Diabetic Foot Mortality Wound Infection Mortality Death Prevention and Control Wound Healing Evaluation Debridement Amputation Diabetic Foot Surgery Wound Infection Surgery Embase PubMed Cochrane Library ab: In recent years, local antibiotic‐loaded bone substitutes (ALBS) have been used increasingly in the treatment of diabetic foot infection (DFI). The meta‐analysis aimed to analyse the efficacy of ALBS on patients with moderate to severe DFI (with or without osteomyelitis). With an appropriate search strategy, 7 studies were selected for analysis (2 RCTs and 5 cohort studies). The result showed that the application of ALBS effectively reduced the length of hospital stay (WMD −5.55; 95% CI: −9.85 to −1.26; P = 0.01), the recurrence rates (RR 0.33; 95% CI: 0.15 to 0.69; P = 0.003) and the mortality rates (RR 0.22; 95% CI: 0.06 to 0.82; P = 0.02). Compared to the control groups, however, there was no difference in healing rates (RR 1.06; 95% CI: 0.96 to 1.18; P = 0.26), healing time (WMD −1.44; 95% CI: −3.37 to −0.49; P = 0.14), the number of debridement (WMD −1.98; 95% CI: −4.08 to 0.12; P = 0.06) and major amputation rates (RR 0.76; 95% CI: 0.35 to 1.61; P = 0.47). The ALBS appears to have some beneficial effects as an adjunct to standard surgery in the treatment of DFI with or without osteomyelitis, as it reduces recurrence rates, mortality rates, and length of hospital stay, but there was no statistically significant difference in enhancing wound healing. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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