Mapping development-related and age-related chromatin remodeling by a high throughput ChIP-HPLC approach.
Common to numerous differentiation pathways in vertebrate organisms is the regulation of key genes through epigenetic mechanisms. Less well studied is to what extent cells of a given differentiation state, but examined at different points within the life history of an organism, are distinct at the l...
| Publicado en: | Journals of Gerontology Series A: Biological Sciences & Medical Sciences Vol. 59; no. 12; pp. 1234 - 1244 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
Dec2004
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=16240178&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 16240178 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10795006 JGA jtl: Journals of Gerontology Series A: Biological Sciences & Medical Sciences issn: 10795006 maglogo: N pubinfo: dt: Dec2004 vid: 59 iid: 12 pid: 622 pub: Oxford University Press / USA artinfo: ui: 16240178 16240178 NLM15699522 10.1093/gerona/59.12.1234 NLM15699522 16240178 ppf: 1234 ppct: 10 formats: tig: atl: Mapping development-related and age-related chromatin remodeling by a high throughput ChIP-HPLC approach. aug: au: Russanova, Valya R. Hirai, Tazuko H. Tchernov, Andrei V. Howard, Bruce H. affil: National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, Maryland sug: subj: Aging Chromosome Mapping Proteins Metabolism Chromatography, High Pressure Liquid Metabolism Genome, Human Polymerase Chain Reaction Coping Health Inventory for Parents ab: Common to numerous differentiation pathways in vertebrate organisms is the regulation of key genes through epigenetic mechanisms. Less well studied is to what extent cells of a given differentiation state, but examined at different points within the life history of an organism, are distinct at the level of the epigenome. A few instances of such variation have been reported, and it would be of considerable value to have at hand a means to characterize additional examples more efficiently. We describe an integrated approach to this task, and further present evidence for regions of age-related histone H4 acetylation change extending over tens to hundreds of kilobases. Broad similarity between two distinct regions of such change suggests a previously unsuspected link between developmental programs and aging. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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