Triple Drug Therapy with Proton Pump Inhibitor a Better Option for Helicobacter Pylori Eradication.
H.Pylori is a gram-negative micro organism residing in the stomach of human. It is a important cause of acid peptic disorders. Bismuth based triple therapy,triple therapy regimens (Tripple PPI) and Quadruple therapy are the available treatment options to eradicate H. pylori. Controversy still presen...
| Publicado en: | Medico-Legal Update Vol. 20; no. 4; pp. 1252 - 1257 |
|---|---|
| Autores principales: | , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Institute of Medico-legal publications Pvt Ltd
Oct-Dec2020
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162449591&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162449591 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0971720X 6CKZ jtl: Medico-Legal Update issn: 0971720X maglogo: N pubinfo: dt: Oct-Dec2020 vid: 20 iid: 4 pid: 50801 pub: Institute of Medico-legal publications Pvt Ltd artinfo: ui: 162449591 162449591 162449591 10.37506/mlu.v20i4.1999 162449591 ppf: 1252 ppct: 5 formats: tig: atl: Triple Drug Therapy with Proton Pump Inhibitor a Better Option for Helicobacter Pylori Eradication. aug: au: R., Lamture Y. Dihare, Thavendra Jaglal Gajbhiye, Varsha Dilip, Gode affil: Professor in Surgery, J.N. Medical college Wardha sug: subj: Drug Therapy, Combination Methods Proton Pump Inhibitors Therapeutic Use Helicobacter Infections Drug Therapy Helicobacter Infections Prevention and Control Human India Clinical Trials Prospective Studies Male Female Young Adult Adult Middle Age Signs and Symptoms Complications Hemostasis, Endoscopic Duodenal Ulcer Peptic Ulcer Bismuth Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: H.Pylori is a gram-negative micro organism residing in the stomach of human. It is a important cause of acid peptic disorders. Bismuth based triple therapy,triple therapy regimens (Tripple PPI) and Quadruple therapy are the available treatment options to eradicate H. pylori. Controversy still presents regarding the superiority of treatment modality and results of available studies are variable. Hence this study was undertaken to evaluate and compare the efficacy of triple PPI, Quadruple therapy, and bismuth-based triple therapy in treating acid peptic disorders and Helicobacter pylori eradication. Method: This study was a prospective interventional. After the establishment of a clinical diagnosis of the acid peptic disorder, the patient was posted for endoscopy. H. pylori status was determined by the rapid urease test and culture examination. All patients divided into three groups and offered three different medical treatments the first group received bismuth bases triple therapy, the second group got Tripple PPI therapy and the third one received quadruple therapy. efficacy and comparison of all these treatment modalities were evaluated and assessed by symptoms, endoscopic findings, and results of the rapid urease test after 6 weeks. Results: In the present study, 150 patients with upper gastrointestinal symptoms were studied It was found that the maximum number of subjects belonged to the age group 31-40 yrs. Male outnumbers than females. Maximum patients had pain in epigastric region and were having gastritis as a commonest diagnosis., Symptomatic relief by Triple therapy with PPI was maximum than other therapies. Rapid urease test (RUT) was also suggest that treatment with it gives superior eradication rates. Discussion: In our study, we have found that the treatment regime with PPI Triple therapy has given maximum symptomatic relief, there is an association of H. Pylori infection in an acid peptic disorder like duodenal ulcer (86.66%), gastric ulcer (75%), and gastritis (82.85%). the efficacy of the Rapid urease test is 66% and that of culture is 38.66% in the diagnosis of H. pylori infection in acid peptic disorder. Conclusion: PPI Triple therapy is most effective in symptomatic relief and healing of the duodenal and peptic ulcer. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|