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A novel digital biomarker of sarcopenia in frail elderly: New combination of gait parameters under dual-task walking.

Background: Frailty caused by deterioration in multiple physiological systems has led to a significant increase in adverse events such as falls, disability, and death in frail older people. Similar to frailty, sarcopenia, defined as loss of skeletal muscle mass and strength, is tightly related to mo...

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Published in:Frontiers in Aging Neuroscience Vol. 15; pp. 1 - 12
Main Authors: Zheping Zhou, Yulun Huang, Jing Wang, Huan Su, Haiying Tang, Yueju Wang
Format: pictorial research tables/charts Journal Article
Published: Frontiers Media S.A. 2/20/2023
Online Access:View this record in EBSCOhost
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      jtl: Frontiers in Aging Neuroscience
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      dt: 2/20/2023
      vid: 15
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      pub: Frontiers Media S.A.
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        10.3389/fnagi.2023.1087318
        162453729
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        atl: A novel digital biomarker of sarcopenia in frail elderly: New combination of gait parameters under dual-task walking.
      aug:
        au:
          Zheping Zhou
          Yulun Huang
          Jing Wang
          Huan Su
          Haiying Tang
          Yueju Wang
        affil: Department of Geratology, The First Affiliated Hospital of Soochow University, Suzhou, China
      sug:
        subj:
          Frail Elderly
          Sarcopenia Diagnosis
          Gait Analysis
          Walking
          Multitasking Behavior
          Task Performance and Analysis
          Wearable Sensors Evaluation
          Predictive Value of Tests Evaluation
          Human
          Male
          Female
          Aged
          Aged, 80 and Over
          China
          Walking Speed
          Agility
          Random Sample
          Cognition
          Descriptive Statistics
          T-Tests
          Mann-Whitney U Test
          Chi Square Test
          Logistic Regression
          Odds Ratio
          Confidence Intervals
          ROC Curve
          Pearson's Correlation Coefficient
          Spearman's Rank Correlation Coefficient
          Data Analysis Software
          Funding Source
          Center for Epidemiological Studies Depression Scale
          Neuropsychological Tests
          Scales
          Aged: 65+ years
          Aged, 80 & over
          Male
          Female
      ab: Background: Frailty caused by deterioration in multiple physiological systems has led to a significant increase in adverse events such as falls, disability, and death in frail older people. Similar to frailty, sarcopenia, defined as loss of skeletal muscle mass and strength, is tightly related to mobility disorders, falls, and fractures. With population aging, co-occurrences of frailty and sarcopenia are increasingly common in the elderly, which are more deleterious for the health and independence of older adults. But the high similarity and overlap between the frailty and sarcopenia increase the difficulty of early recognition of frailty with sarcopenia. The purpose of this study is to use detailed gait assessment to determine the more convenient and sensitive digital biomarker of sarcopenia in the frail population. Methods: Ninety-five frail elderly people (age = 86 ± 7 years old, BMI, and body mass index = 23.21 ± 3.40 kg/m2) were screened out by the evaluation of Fried criteria. Then, 41 participants (46%) were identified with sarcopenia, and 51 participants (54%) were identified without sarcopenia. Using a validated wearable platform, participants' gait performance was evaluated under single-task and dual-task (DT). Participants walked back and forth on the 7-m-long trail for 2 min at a habitual speed. Gait parameters of interest include cadence, gait cycle duration, step duration, gait speed, variability of gait speed, stride length, turn duration, and steps in turn. Results: Our results showed that compared with the frail elderly without sarcopenia, the gait performance of the sarcopenic group in single-task and dual-task walking was worse. Overall, the parameters with high performance were the gait speed (DT) (OR 0.914; 95% CI 0.868-0.962) and turn duration (DT) (OR 7.907; 95% CI 2.401-26.039) under dual-task conditions, and the AUC in distinguishing between frail older adults with and without sarcopenia was 0.688 and 0.736, respectively. Turn duration in dual-task testing had larger observed effect than gait speed to identify sarcopenia in the frail population, this result remained significant even after controlling for potential confounds. When gait speed (DT) and turn duration (DT) were combined in the model, AUC increased from 0.688 to 0.763. Conclusion: This study shows that gait speed and turn duration under dual-task are good predictors of sarcopenia in frail elderly, and turn duration (DT) has a better predictive ability. The gait speed (DT) combined with turn duration (DT) is a potential gait digital Biomarker of sarcopenia in the frail elderly. Dual-task gait assessment and detailed gait indexes provide important value for identification of sarcopenia in frail elderly people.
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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