Lycium chinense Miller fruit extract lowers liver enzyme levels in subjects with mild hepatic dysfunction: a randomized, double-blind, placebo-controlled clinical trial.
Purpose: In our previous study, we showed that Lycium chinense Miller fruit extract (LFE) exerted hepatoprotective effects in mice. In the current study, we examined the effect of LFE on liver enzyme levels in subjects with mild hepatic dysfunction. Methods: A total of 90 subjects, aged 19 to 70 yea...
| Publicado en: | European Journal of Nutrition Vol. 62; no. 3; pp. 1415 - 1426 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Apr2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162586876&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162586876 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2023 vid: 62 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 162586876 161251739 162586876 162586876 10.1007/s00394-022-03075-8 162586876 ppf: 1415 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Lycium chinense Miller fruit extract lowers liver enzyme levels in subjects with mild hepatic dysfunction: a randomized, double-blind, placebo-controlled clinical trial. aug: au: Oh, Mi-Ra Jung, Su-Jin Chae, Soo-Wan Park, Byung-Hyun Lee, Seung-Ok affil: Clinical Trial Center for Functional Foods, Jeonbuk National University Hospital, 54907, Jeonju, Jeonbuk, Republic of Korea sug: subj: Liver Diseases Drug Therapy Fruit Plant Extracts Pharmacodynamics Liver Drug Effects Enzymes Drug Effects Human Randomized Controlled Trials Double-Blind Studies Male Female Adult Middle Age Aged Alanine Aminotransferase gamma-Glutamyltransferase Treatment Outcomes Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: In our previous study, we showed that Lycium chinense Miller fruit extract (LFE) exerted hepatoprotective effects in mice. In the current study, we examined the effect of LFE on liver enzyme levels in subjects with mild hepatic dysfunction. Methods: A total of 90 subjects, aged 19 to 70 years old, with abnormal alanine aminotransferase (ALT) levels, were randomly placed into either an LFE (n = 45) treatment group or a placebo group (n = 45). During the 12-week clinical trial, subjects in each group received either LFE or placebo capsules, and were instructed to take four tablets per day (1760 mg/day). The primary outcome of the study was the changes of ALT and γ-glutamyltransferase (GGT) levels in each subject. The safety of LFE supplementation was assessed and adverse events were recorded. Results: LFE supplementation for 12 weeks resulted in a significant reduction of ALT (P = 0.0498) and GGT (P = 0.0368) levels in comparison to the placebo. No clinically significant changes were observed in any safety parameters. Conclusion: These results suggest that LFE can be applied to subjects with mild hepatic dysfunction with no possible side effects. Trial registration: This study was registered at the Clinical Research Information Service (CRIS) as no. KCT0003985. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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