Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training.
Purpose: Reactive oxygen and nitrogen species are required for exercise-induced molecular adaptations; however, excessive exercise may cause cellular oxidative distress. We postulate that astaxanthin (ASX) can neutralize oxidative distress and stimulate mitochondrial biogenesis in high-intensity exe...
| Publicado en: | European Journal of Nutrition Vol. 62; no. 3; pp. 1453 - 1467 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Apr2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162586882&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162586882 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Apr2023 vid: 62 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 162586882 161373955 162586882 162586882 10.1007/s00394-023-03083-2 162586882 ppf: 1453 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Astaxanthin promotes mitochondrial biogenesis and antioxidant capacity in chronic high-intensity interval training. aug: au: Wang, Yang Chen, Xiaoping Baker, Julien S. Davison, Gareth W. Xu, Shujun Zhou, Yingsong Bao, Xiaoming affil: Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, People's Republic of China sug: subj: Carotenoids Pharmacodynamics Cell Physiology Drug Effects Mitochondria Drug Effects Oxidative Stress Drug Effects High-Intensity Interval Training Animal Studies Mice Reactive Oxygen Species Drug Effects Gene Expression Drug Effects Carotenoids Administration and Dosage Exercise Intensity Gastrocnemius Muscle Physiology Malondialdehyde Blood AMP-Activated Protein Kinases Drug Effects Transferases Drug Effects Transcription Factors Drug Effects ab: Purpose: Reactive oxygen and nitrogen species are required for exercise-induced molecular adaptations; however, excessive exercise may cause cellular oxidative distress. We postulate that astaxanthin (ASX) can neutralize oxidative distress and stimulate mitochondrial biogenesis in high-intensity exercise-trained mice. Methods: Six-week-old mice (n = 8/group) were treated with ASX (10 mg/kg BW) or placebo. Training groups participated in 30 min/day high-intensity interval training (HIIT) for 6 weeks. Gastrocnemius muscle was collected and assayed following the exercise training period. Results: Compared to the HIIT control mice, the ASX-treated HIIT mice reduced malonaldehyde levels and upregulated the expression of Nrf2 and FOXO3a. Meanwhile, the genes NQO1 and GCLC, modulated by Nrf2, and SOD2, regulated by FOXO3a, and GPx4, were transcriptionally upregulated in the ASX-treated HIIT group. Meanwhile, the expression of energy sensors, AMPK, SIRT1, and SIRT3, increased in the ASX-treated HIIT group compared to the HIIT control group. Additionally, PGC-1α, regulated by AMPK and SIRT1, was upregulated in the ASX-treated HIIT group. Further, the increased PGC-1α stimulated the transcript of NRF1 and Tfam and mitochondrial proteins IDH2 and ATP50. Finally, the ASX-treated HIIT mice had upregulations in the transcript level of mitochondrial fusion factors, including Mfn1, Mfn2, and OPA1. However, the protein level of AMPK, SIRT1, and FOXO3a, and the transcript level of Nrf2, NQO1, PGC-1α, NRF1, Mfn1, Mfn2, and OPA1 decreased in the HIIT control group compared to the sedentary control group. Conclusion: Supplementation with ASX can reduce oxidative stress and promote antioxidant capacity and mitochondrial biogenesis during strenuous HIIT exercise in mice. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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