[68Ga]Ga-FAPI-04 PET/CT on assessing Crohn's disease intestinal lesions.
Background: Fibrosis and inflammation are major pathological changes of Crohn's disease (CD). Early detection and accurate severity evaluation of CD are critical for patient's prognosis. Endoscopy is widely used to evaluate CD progression. Herein, we evaluated the efficacy of [68Ga]Ga-FAPI-04 PET/CT...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 50; no. 5; pp. 1360 - 1371 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162587719&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162587719 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Apr2023 vid: 50 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 162587719 161251752 10.1007/s00259-023-06107-5 162587719 ppf: 1360 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: [68Ga]Ga-FAPI-04 PET/CT on assessing Crohn's disease intestinal lesions. aug: au: Chen, Liming Zhong, Xiaolin Li, Limin Li, Xue Liu, Ya Guo, Chunmei Chen, Yue Huang, Zhanwen affil: Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, Sichuan, People's Republic of China sug: ab: Background: Fibrosis and inflammation are major pathological changes of Crohn's disease (CD). Early detection and accurate severity evaluation of CD are critical for patient's prognosis. Endoscopy is widely used to evaluate CD progression. Herein, we evaluated the efficacy of [68Ga]Ga-FAPI-04 PET/CT to identify lesions and assess the progression of CD. Methods: All CD patients received computed tomography enterography (CTE), [68Ga]Ga-FAPI-04 PET/CT examination, and ileocolonoscopy within 1 week. Two independent gastroenterologists computed the Crohn's disease activity index (CDAI) of all patients. Two radiology physicians assessed the CTE images separately, and the CTE scores were calculated. Lastly, two nuclear medicine physicians independently examined the [68Ga]Ga-FAPI-04 PET/CT images. Once the FAPI uptake of the intestinal segment was equal or higher relative to the liver (considered FAPI-positive), the target-to-background ratio (TBR) and global FAPI PET/CT score were computed, representing the independent intestinal activity and activity of all intestinal segments, respectively. Levels of fecal calprotectin (FCP) and C-reactive protein (CRP) were determined before the endoscopy. The Crohn's disease endoscopy index of severity (CDEIS) and the simple endoscopic score for Crohn's disease (SES-CD) were calculated during the endoscopy. Finally, all data were obtained and analyzed. Results: There were 74 intestinal segments in 16 patients were assessed. [68Ga]Ga-FAPI-04 PET/CT identified 42 of 45 endoscopically lesioned segments (endoscopic lesions detection sensitivity: 93.3%), while CTE identified 39 of them (endoscopic lesions detection sensitivity: 86.7%). According to the receiver operating characteristic (ROC) analysis, [68Ga]Ga-FAPI-04 PET/CT showed better performance in the detection of endoscopic lesions compared with CTE (P < 0.05). The TBR was significantly associated with the CTE score (r = 0.81; (95% CI): 0.736–0.869; P < 0.0001) and SES-CD values (r = 0.86; (95% CI): 0.776–0.908; P < 0.0001). In addition, the global FAPI PET/CT score was significantly correlated with FCP (r = 0.52; 95% CI, 0.02–0.81; P = 0.039), CRP (r = 0.60; 95% CI, 0.13–0.85; P = 0.014), CDEIS (r = 0.55; 95% CI, 0.06–0.83; P = 0.028), and CDAI (r = 0.81; 95% CI, 0.50–0.93; P < 0.0001). Conclusion: In summary, [68Ga]Ga-FAPI-04 PET/CT correlated well with endoscopic, CTE, clinical, and biomarkers of CD. It was also highly sensitive in the detection of different classes of lesions in all intestinal segments, and unlike other examinations, this technique required no patient fasting or bowel preparation. Therefore, [68Ga]Ga-FAPI-04 PET/CT may be a promising method for assessing the activity of CD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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