The management of polypharmacy in people living with HIV.
Antiretroviral therapy (ART) has modified the prognosis of HIV which has evolved into a chronic condition. People living with HIV (PLWH) are living longer presenting an increased number of comorbidities leading to polypharmacy. Literature on the prevalence, associated factors, drug-drug interactions...
| Publicado en: | AIDS Reviews Vol. 25; no. 1; pp. 27 - 41 |
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| Autores principales: | , , , , , , , |
| Formato: | Artículo |
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Publicidad Permanyer SLU
Jan-Mar2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=162694632&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 162694632 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 11396121 3PWJ jtl: AIDS Reviews issn: 11396121 maglogo: N pubinfo: dt: Jan-Mar2023 vid: 25 iid: 1 pid: 37650 pub: Publicidad Permanyer SLU artinfo: ui: 162694632 10.24875/AIDSRev.M23000059 ppf: 27 ppct: 14 formats: fmt: @attributes: type: P size: 608KB tig: atl: The management of polypharmacy in people living with HIV. aug: au: Marin, Sergio Quiñones, Carles Jiménez, Carla Codina Valls, Ester Terricabras, Eva Estrada, Lidia Cardona, Glòria Andreu, Àngels affil: Department of Pharmacy, Hospital Universitari Germans Trias i Pujol, Badalona, Spain sug: keyword: Aging Antiretroviral agents Drug interactions HIV Malnutrition Polypharmacy Sarcopenia Treatment adherence and compliance Treatment outcome ab: Antiretroviral therapy (ART) has modified the prognosis of HIV which has evolved into a chronic condition. People living with HIV (PLWH) are living longer presenting an increased number of comorbidities leading to polypharmacy. Literature on the prevalence, associated factors, drug-drug interactions (DDIs), effects on ART-outcomes, geriatric conditions, and nutritional status together with health-interventions aimed to reduce it is presented in this review. A literature search was conducted on the MEDLINE database for all relevant English- and Spanish-language studies since 2006. Studies providing data of interest were identified and ordered in groups: (i) prevalence and associated factors (n = 37), (ii) DDIs (n = 19), (iii) Effects on ART-outcomes (n = 12), (iv) Effects on health conditions (n = 13), and (V) Health-interventions to assess and/or reduce it (n = 9). Polypharmacy occurs in 9-91% of PLWH (2.6-19.5% affected by severe polypharmacy). Main factors associated with polypharmacy are older age, a higher number of comorbidities, frailty, deteriorated renal function, and previous hospitalizations. DDIs were present in 19.15-84% of cases (1.3-12.2% for the most severe types). Mainly involved non-ART drugs were antihypertensives, statins, antithrombotic agents, corticosteroids, divalent cations, and antiacids. Polypharmacy can affect ART selection, adherence, and outcomes and has been related to some geriatric conditions such as falls, frailty, and poor nutritional status. Potentially prescribing issues are present in up to 87.9% of cases according to the STOPPSTART and Beers criteria and some pharmacist-led interventions have been shown to reduce it. Considering these findings, polypharmacy should be considered a clinical concern in this population and treatment-optimization programs are needed to reduce its burden. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of AIDS Reviews is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: AIDS Reviews holder: Publicidad Permanyer SLU dt: @attributes: year: 2023 holdings: @attributes: islocal: N |
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