Anal Cancer: The Past, Present and Future.
Anal cancer is a rare cancer that accounts for about 2% of all gastrointestinal tract malignancies. Among anal cancer, squamous cell cancer is the most common malignancy. The incidence of all stages of anal squamous cell cancer has been increasing. Human papillomavirus infection and immunosuppressio...
| Publicado en: | Current Oncology Vol. 30; no. 3; pp. 3232 - 3251 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
MDPI
Mar2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162747213&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162747213 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: Mar2023 vid: 30 iid: 3 pid: 97109 pub: MDPI artinfo: ui: 162747213 10.3390/curroncol30030246 162747213 ppf: 3232 ppct: 19 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Anal Cancer: The Past, Present and Future. aug: au: Gondal, Talha Ashraf Chaudhary, Noman Bajwa, Husnaat Rauf, Aribah Le, Duc Ahmed, Shahid affil: College of Medicine, University of Saskatchewan, Saskatoon, SK S7N5E5, Canada sug: ab: Anal cancer is a rare cancer that accounts for about 2% of all gastrointestinal tract malignancies. Among anal cancer, squamous cell cancer is the most common malignancy. The incidence of all stages of anal squamous cell cancer has been increasing. Human papillomavirus infection and immunosuppression are major risk factors for anal cancer. The management of anal cancer has evolved over the past several decades and continues to do so. Chemoradiation therapy remains the mainstay for treatment for most patients with early-stage disease, whereas systemic therapy is the primary treatment for patients with metastatic disease. Patients with persistent disease or recurrence following chemoradiation therapy are treated with salvage surgery. Access to novel cytotoxic combinations and immunotherapy has improved the outcomes of patients with advanced disease. This review provides an overview of advances in the management of anal cancer over the past two decades. This paper reviews the epidemiology, risk factors, pathology, diagnosis, and management of localized and advanced anal squamous cell cancer, highlights current knowledge gaps in the management of anal cancer, and discusses future directions. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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