Prognostic Value of Programmed Death Ligand-1 in Discriminating Patients With Lymph Node--Negative, p53--Wild-Type, or Low-BRCA1/2-Expression Pancreatic Ductal Adenocarcinoma.
Context.--Alterations in the tumor microenvironment affect the response to immunotherapy and are associated with clinical outcomes. However, the role of B7 family checkpoint molecules in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Objective.--To investigate the expression of programmed...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 147; no. 4; pp. 465 - 474 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Apr2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162751650&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162751650 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Apr2023 vid: 147 iid: 4 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 162751650 162751650 162751650 10.5858/arpa.2021-0471-OA 162751650 ppf: 465 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Prognostic Value of Programmed Death Ligand-1 in Discriminating Patients With Lymph Node--Negative, p53--Wild-Type, or Low-BRCA1/2-Expression Pancreatic Ductal Adenocarcinoma. aug: au: Xianlong Chen Yue Zhang Shengwei Mo Heng Ma Zhaohui Lu Shuangni Yu Jie Chen affil: Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China sug: subj: Adenocarcinoma Prognosis Carcinoma, Ductal Prognosis Pancreatic Neoplasms Prognosis Programmed Cell Death Ligand 1 Gene Expression Genes, BRCA Human Descriptive Statistics Data Analysis Software Chi Square Test Fisher's Exact Test Kaplan-Meier Estimator Confidence Intervals Log-Rank Test Univariate Statistics Multivariate Analysis Cox Proportional Hazards Model Biological Assay Immunohistochemistry ab: Context.--Alterations in the tumor microenvironment affect the response to immunotherapy and are associated with clinical outcomes. However, the role of B7 family checkpoint molecules in pancreatic ductal adenocarcinoma (PDAC) remains unclear. Objective.--To investigate the expression of programmed death ligand-1 (PD-L1), B7 homolog 3 (B7-H3), and B7 homolog 4 (B7-H4) and the association of these molecules with pathologic features, DNA damage repair (DDR) molecules, immune infiltrates, and survival in PDAC. Design.--The expression of B7 family molecules, densities of immune cells, and DDR status were evaluated by using immunohistochemical assays in tissue microarrays. Results.--Positive PD-L1 expression on tumor cells (TCs) and stromal cells (SCs) was observed in 30.3% (80 of 264) and 20.5% (54 of 264) of patients, respectively, whereas B7-H3 showed positivity in 81.3% (195 of 240) and 87.9% (211 of 240) of patients, respectively. B7-H4 was detected exclusively in tumor cells, with a positivity rate of 76.0% (193 of 254). PD-L1 on TCs was an independent predictor of worse disease-free survival, whereas B7-H3 on TCs was an independent factor of improved survival. The prognostic significance of PD-L1 was more discriminative in lymph node--negative, p53--wild-type, and low-BRCA1/2-expression tumors. B7-H3 on SCs was negatively correlated with CD45RO T cells, whereas PD-L1 on SCs was related to high densities of CD3, CD4, CD8, CD45RO, and Foxp3 T cells and B7-H4 was more common in tumors with a low CD8 status. Conclusions.--We identified B7 family checkpoint molecules as potentially prognostic indicators, combined with different DDR molecular statuses and complex immune infiltrates, in PDAC. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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