Epidemiology and clinicopathological characteristics of native kidney disease in children in Flanders, Belgium.
Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is a population-based kidney biopsy registry that has been including all native kidney biopsies performed in children in Flanders (Belgium), since 2017. Methods: From 2017 to 2020, 148 pediatric (< 18 years) native kidney...
| Publicado en: | Pediatric Nephrology Vol. 38; no. 5; pp. 1533 - 1546 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162755582&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162755582 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: May2023 vid: 38 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 162755582 159645437 162755582 162755582 10.1007/s00467-022-05719-7 162755582 ppf: 1533 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Epidemiology and clinicopathological characteristics of native kidney disease in children in Flanders, Belgium. aug: au: Deleersnijder, Dries Knops, Noël Trouet, Dominique Van Hoeck, Koen Karamaria, Sevasti Vande Walle, Johan Mauel, Reiner Cools, Louise Meeus, Gert Dendooven, Amélie De Meester, Johan Laurens, Wim Sprangers, Ben affil: Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Louvain, Belgium sug: subj: Kidney Diseases Human Belgium Child Kidney Pathology Biopsy Funding Source Kidney Diseases Diagnosis Diagnosis, Urologic Clinical Assessment Tools Severity of Illness Kidney Diseases Risk Factors Age Factors Sex Factors Descriptive Statistics Glomerular Filtration Rate Prevalence Genetic Techniques Kidney Diseases Epidemiology Kidney Diseases Symptoms Kidney Diseases Pathology Child: 6-12 years ab: Background: The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is a population-based kidney biopsy registry that has been including all native kidney biopsies performed in children in Flanders (Belgium), since 2017. Methods: From 2017 to 2020, 148 pediatric (< 18 years) native kidney biopsies were included. Each biopsy received a histopathological and final nephrological diagnosis, and concordance between both was assessed. Disease chronicity, summarized by the Mayo Clinic Chronicity Score, was determined on 122 biopsies with > 5 glomeruli. Results: Kidney biopsy rate was high (29.0 biopsies per million children per year), median age was 10.0 years (IQR 5.8–14.7), and boys predominated (56.1% males). A total of 140 biopsies (94.6%) showed a representative pathology result. Glomerular disease was most prevalent, with IgA nephropathy/IgA vasculitis (43 biopsies, 29.1%) and minimal change disease (MCD) (29 biopsies, 19.6%) being the overall most frequent diagnoses. In general, diagnostic concordance was high (80.7%). In Alport syndrome and focal segmental glomerulosclerosis (FSGS), concordance was lower, as the nephrological diagnosis was often determined by results of genetic analysis. Nephrotic syndrome was the most frequent indication for kidney biopsy (31.8%) and was mainly caused by MCD and FSGS. The degree of disease chronicity on kidney biopsies was generally low, although 27.3% of biopsies with a diagnosis of FSGS showed moderate-to-severe chronic damage. Conclusions: The presented epidemiological findings validate data from previous European registry studies and may inspire kidney biopsy registries worldwide to implement novel features such as clinicopathological concordance and chronicity grading. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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