Early detection of cognitive decline in Alzheimer’s disease using eye tracking.
Background: Patients with Alzheimer’s disease (AD) are known to exhibit visuospatial processing impairment, as reflected in eye movements from the early stages of the disease. We investigated whether the pattern of gaze exploration during visual tasks could be useful for detecting cognitive decline...
| Publicado en: | Frontiers in Aging Neuroscience Vol. 15; pp. 1 - 16 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
3/21/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162903166&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162903166 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 3/21/2023 vid: 15 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 162903166 162903166 162903166 10.3389/fnagi.2023.1123456 162903166 ppf: 1 ppct: 15 formats: tig: atl: Early detection of cognitive decline in Alzheimer’s disease using eye tracking. aug: au: Shin-ichi Tokushige Hideyuki Matsumoto Shun-ichi Matsuda Satomi Inomata-Terada Naoki Kotsuki Masashi Hamada Shoji Tsuji Yoshikazu Ugawa Yasuo Terao affil: Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. sug: subj: Cognition Evaluation Alzheimer's Disease Risk Factors Eye Movements Evaluation Human Aged Aged, 80 and Over Descriptive Statistics Task Performance and Analysis Sensitivity and Specificity Saccades Dementia Memory Disorders Neurodegenerative Diseases Quality of Life T-Tests Neuropsychological Tests Data Analysis Software Post Hoc Analysis Mann-Whitney U Test Two-Way Analysis of Variance Pearson's Correlation Coefficient ROC Curve Aged: 65+ years Aged, 80 & over ab: Background: Patients with Alzheimer’s disease (AD) are known to exhibit visuospatial processing impairment, as reflected in eye movements from the early stages of the disease. We investigated whether the pattern of gaze exploration during visual tasks could be useful for detecting cognitive decline at the earliest stage. Methods: Sixteen AD patients (age: 79.1 ± 7.9 years, Mini Mental State Examination [MMSE] score: 17.7 ± 5.3, mean ± standard deviation) and 16 control subjects (age: 79.4 ± 4.6, MMSE score: 26.9 ± 2.4) participated. In the visual memory task, subjects memorized presented line drawings for later recall. In the visual search tasks, they searched for a target Landolt ring of specific orientation (serial search task) or color (pop-out task) embedded among arrays of distractors. Using videooculography, saccade parameters, patterns of gaze exploration, and pupil size change during task performance were recorded and compared between AD and control subjects. Results: In the visual memory task, the number of informative regions of interest (ROIs) fixated was significantly reduced in AD patients compared to control subjects. In the visual search task, AD patients took a significantly longer time and more saccades to detect the target in the serial but not in pop-out search. In both tasks, there was no significant difference in the saccade frequency and amplitude between groups. On-task pupil modulation during the serial search task was decreased in AD. The number of ROIs fixated in the visual memory task and search time and saccade numbers in the serial search task differentiated both groups of subjects with high sensitivity, whereas saccade parameters of pupil size modulation were effective in confirming normal cognition from cognitive decline with high specificity. Discussion: Reduced fixation on informative ROIs reflected impaired attentional allocation. Increased search time and saccade numbers in the visual search task indicated inefficient visual processing. Decreased on-task pupil size during visual search suggested decreased pupil modulation with cognitive load in AD patients, reflecting impaired function of the locus coeruleus. When patients perform the combination of these tasks to visualize multiple aspects of visuospatial processing, cognitive decline can be detected at an early stage with high sensitivity and specificity and its progression be evaluated. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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