Mac-2 binding protein glycosylation isomer (M2BPGi) to evaluate liver fibrosis and cancer in HBV-infected patients in West Africa.
Background: To reduce mortality associated with hepatitis B virus (HBV) infection, timely detection of cirrhosis and early-stage hepatocellular carcinoma (HCC) is essential. In low-income countries, however, HBV-infected people have limited access to liver histopathology, a reference test. Recently,...
| Published in: | Journal of Global Health Vol. 12; pp. 1 - 13 |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Edinburgh University Global Health Society
2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=162935859&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 162935859 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20472978 DBQG jtl: Journal of Global Health issn: 20472978 maglogo: N pubinfo: dt: 2022 vid: 12 pid: 72708 pub: Edinburgh University Global Health Society artinfo: ui: 162935859 162935859 NLM36370422 162935859 10.7189/jogh.12.04076 NLM36370422 162935859 ppf: 1 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Mac-2 binding protein glycosylation isomer (M2BPGi) to evaluate liver fibrosis and cancer in HBV-infected patients in West Africa. aug: au: Perpétue Vincent, Jeanne Ndow, Gibril Shintaro Ogawa Ceesay, Amie Njie, Ramou Sanneh, Bakary Baldeh, Ignatius D'Alessandro, Umberto Mendy, Maimuna Thursz, Mark Chemin, Isabelle Yasuhito Tanaka Lemoine, Maud Yusuke Shimakawa Vincent, Jeanne Perpétue Ogawa, Shintaro Tanaka, Yasuhito Shimakawa, Yusuke affil: Unité d'Épidémiologie des Maladies Émergentes, Institut Pasteur, Paris, France sug: subj: Carcinoma, Hepatocellular Complications Carcinoma, Hepatocellular Metabolism Liver Neoplasms Metabolism Hepatitis B Diagnosis Carcinoma, Hepatocellular Diagnosis Liver Neoplasms Diagnosis Liver Neoplasms Complications Hepatitis B Complications Cross Sectional Studies Liver Cirrhosis Complications Liver Cirrhosis Diagnosis Hepatitis Viruses Glycosylation Scales Human ab: Background: To reduce mortality associated with hepatitis B virus (HBV) infection, timely detection of cirrhosis and early-stage hepatocellular carcinoma (HCC) is essential. In low-income countries, however, HBV-infected people have limited access to liver histopathology, a reference test. Recently, Asian studies have suggested the usefulness of an inexpensive serum biomarker called Mac-2 binding protein glycosylation isomer (M2BPGi) in staging liver fibrosis and predicting HCC in HBV-infected patients.Methods: We systematically searched PubMed for studies examining the performance of M2BPGi in staging liver fibrosis in HBV-infected people, published up to September 21, 2021, to elucidate the knowledge gap. We then conducted a cross-sectional study of 339 HBV-infected patients in The Gambia (cirrhosis = 65, HCC = 73, non-cirrhosis non-HCC = 201). We evaluated the association of M2BPGi with cirrhosis and HCC by computing odds ratios (ORs) derived from logistic regression. We also assessed the performance of M2BPGi to stage liver fibrosis in 49 patients who underwent liver biopsy (derivation set) and 217 patients with transient elastography (validation set). Using the derivation set we drew the receiver operating characteristics (ROC) curves to identify optimal M2BPGi thresholds to indicate significant fibrosis and cirrhosis using biopsy as a reference. We then applied these cut-offs to the validation set to obtain its sensitivity and specificity for indicating significant fibrosis and cirrhosis using transient elastography as a reference.Results: The systematic review identified 13 studies, all of which were conducted in East Asia and none in Africa. In The Gambia, positive M2BPGi was significantly associated with both cirrhosis (adjusted OR = 7.8, 95% CI = 3.1-19.7) and HCC (adjusted OR = 10.1, 2.6-40.2). The areas under the ROC curve (AUROC) in the derivation and validation set were 0.62 and 0.78, respectively, to diagnose significant fibrosis, and 0.80 and 0.89, respectively, to diagnose cirrhosis. By applying the optimal cut-offs, the sensitivity and specificity in the validation set were 61.5% and 93.4%, respectively, to diagnose significant fibrosis, and 72.5% and 92.2%, respectively, for cirrhosis.Conclusions: To the best of our knowledge, this is the first evaluation of M2BPGi in HBV-infected African population. The findings supported its accuracy in the diagnosis of cirrhosis in HBV-infected patients in West Africa. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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