Clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of pyoderma gangrenosum.
This study was aimed to evaluate the clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of ulcer wound of patients with pyoderma gangrenosum (PG). From August 2014 to February 2022, 30 patients with pyoderma gangre...
| Publicado en: | International Wound Journal Vol. 20; no. 5; pp. 1491 - 1498 |
|---|---|
| Autores principales: | , , , , |
| Formato: | pictorial research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
May2023
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163020566&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163020566 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17424801 1725 jtl: International Wound Journal issn: 17424801 maglogo: Y pubinfo: dt: May2023 vid: 20 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 163020566 159968649 163020566 163020566 10.1111/iwj.14003 163020566 ppf: 1491 ppct: 7 formats: tig: atl: Clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of pyoderma gangrenosum. aug: au: Hao, Yonghong He, Juan Zhao, Zigang Li, Chengxin Feng, Zheng affil: Department of Dermatology, The First Medical Center, The PLA General Hospital, Beijing, China sug: subj: Surgical Flaps Drainage Methylprednisolone Therapeutic Use Cyclosporine Therapeutic Use Pyoderma Gangrenosum Drug Therapy Vacuum Methods Treatment Outcomes Human Random Assignment Control Group Nonexperimental Studies Retrospective Design Immunosuppressive Agents Wound Healing Quality of Life Blood Circulation Randomized Controlled Trials ab: This study was aimed to evaluate the clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of ulcer wound of patients with pyoderma gangrenosum (PG). From August 2014 to February 2022, 30 patients with pyoderma gangrenosum ulcer wounds were selected as the research objects and randomly divided into the observation group (n = 12) and the control group (n = 18) in this retrospective study. The patients in observation group were treated with VSD combined with flap transplantation and immunosuppressive agent treatment, while the control group was treated with normal dressing change combined with hormone and cyclosporine. The ulcer wound healing time and dressing change times were compared between the two groups. All the 30 cases of two groups healed after corresponding treatment. The wound healing time of ulcer in the observation group was 35–40 days, with an average healing time of (35.83 ± 1.95) days, and the wound healing time of the control group was 60–200 days, with an average healing time of (44.14 ± 9.67) days. The healing time of observation groups was significantly shorter than that in the control group (t = 4.652, P <.05). The frequency of dressing change in the observation group was seven–eight times, with an average of (7.17 ± 0.39) times, and the frequency of dressing change in the control group was 75–86 times, with an average of (79.22 ± 3.62) times. The difference between the two groups was significant (t = 6.214, P <.05). The treatment of VSD combined with flap transplantation and immunosuppressive agent treatment promote ulcer wound healing of pyoderma gangrenosum. pubtype: Academic Journal doctype: pictorial research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|