Triglyceride-Glucose Index Cutoff Point Is an Accurate Marker for Predicting the Prevalence of Metabolic Syndrome in Obese Caucasian Subjects.
Background: Recently, the triglyceride-glucose (TyG) index has been suggested as a surrogate insulin resistance marker. This index could act as an early screening marker in individuals with a high risk of metabolic syndrome (MS) such as obese subjects. Aims: The objective of this work was to detect...
| Published in: | Annals of Nutrition & Metabolism Vol. 79; no. 2; pp. 70 - 78 |
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| Main Authors: | , , |
| Format: | research tables/charts Journal Article |
| Published: |
Karger AG
2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163087860&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163087860 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02506807 8BM jtl: Annals of Nutrition & Metabolism issn: 02506807 maglogo: N pubinfo: dt: 2023 vid: 79 iid: 2 pid: 2485 pub: Karger AG artinfo: ui: 163087860 163087860 163087860 10.1159/000526988 163087860 ppf: 70 ppct: 8 formats: tig: atl: Triglyceride-Glucose Index Cutoff Point Is an Accurate Marker for Predicting the Prevalence of Metabolic Syndrome in Obese Caucasian Subjects. aug: au: Primo, David Izaola, Olatz de Luis, Daniel A. affil: Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valladolid, Investigation Centre on Endocrinology and Nutrition (IEN), University of Valladolid, Valladolid, Spain sug: subj: Metabolic Syndrome X Epidemiology Obesity White Persons Psychosocial Factors Forecasting Triglycerides Blood Blood Glucose Biological Markers Blood Metabolic Syndrome X Risk Factors Human Comparative Studies Cross Sectional Studies Blood Pressure Insulin Blood Insulin Resistance Lipids Blood C-Reactive Protein Blood Adipokines Blood Descriptive Statistics Male Female Adult Middle Age Sensitivity and Specificity Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Recently, the triglyceride-glucose (TyG) index has been suggested as a surrogate insulin resistance marker. This index could act as an early screening marker in individuals with a high risk of metabolic syndrome (MS) such as obese subjects. Aims: The objective of this work was to detect the cutoff point of the TyG index for the diagnosis of MS according to ATPIII criteria on obese subjects and to compare with HOMA-IR. Methods: We conducted a cross-sectional study in 1,494 obese subjects. Measurements of adiposity parameters, blood pressure, fasting blood glucose, insulin concentration, insulin resistance (HOMA-IR), lipid profile, C-reactive protein, adipokines, and the prevalence of MS were determined. The TyG index was calculated from the next equation: Ln (fasting triglycerides (mg/dL) × fasting glucose (mg/dL))/2. Results: A total of 1,494 subjects were recruited, 421 males (28.1%) and 1,073 females (71.8%), with an average age of 45.8 ± 15.3 years (range: 29–62). A total of 677 subjects had MS (45.5%) and 817 did not show MS (54.6%). The averages of HOMA-IR and TyG index values increased as the components of MS were aggregated, and both indexes were higher in subjects with MS. The area under the curve (AUC) of the TyG index according to ATPIII criteria showed values of 0.746 (0.721–0.771; p = 0.001). The cutoff point according to the Youden index was 4.72, with sensitivity and specificity of 87% and 88.2%, respectively. For the HOMA-IR, AUC showed values of 0.682 (0.654–0.710; p = 0.01). The cutoff point was 3.23, with sensitivity and specificity of 78% and 70.1%, respectively. Conclusions: The TyG index is more powerful for predicting MS than HOMA-IR in Caucasian obese subjects. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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