SPATA2 suppresses epithelial‐mesenchymal transition to inhibit metastasis and radiotherapy sensitivity in non–small cell lung cancer via impairing DVL1/β‐catenin signaling.
Metastasis is the major cause of cancer‐related death of cancer patients. Epithelial‐mesenchymal transition (EMT) is one critical process during the cascade of tumor metastasis. EMT is a developmental program exploited by cancer cells to transition from epithelial state to mesenchymal state and conf...
| Publicado en: | Thoracic Cancer Vol. 14; no. 11; pp. 969 - 983 |
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| Autores principales: | , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Apr2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163094732&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163094732 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17597706 BDCY jtl: Thoracic Cancer issn: 17597706 maglogo: Y pubinfo: dt: Apr2023 vid: 14 iid: 11 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 163094732 162020772 163094732 163094732 10.1111/1759-7714.14828 163094732 ppf: 969 ppct: 14 formats: tig: atl: SPATA2 suppresses epithelial‐mesenchymal transition to inhibit metastasis and radiotherapy sensitivity in non–small cell lung cancer via impairing DVL1/β‐catenin signaling. aug: au: Ji, Hongbo Zhang, Lu Zou, Man Sun, Yanchen Dong, Xiaohan Mi, Zeyun Meng, Maobin Yuan, Zhiyong Wu, Zhiqiang affil: Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin, China sug: subj: Carcinoma, Non-Small-Cell Lung Physiopathology Carcinoma, Non-Small-Cell Lung Radiotherapy Carcinoma, Non-Small-Cell Lung Prognosis Tumor Markers, Biological Analysis Epithelial-Mesenchymal Transition Neoplasm Metastasis Prevention and Control Signal Transduction Phosphoproteins Metabolism Gene Expression Profiling Funding Source Human Animal Studies Mice In Vitro Studies Data Mining In Vivo Studies Models, Biological Treatment Outcomes Cell Movement ab: Metastasis is the major cause of cancer‐related death of cancer patients. Epithelial‐mesenchymal transition (EMT) is one critical process during the cascade of tumor metastasis. EMT is a developmental program exploited by cancer cells to transition from epithelial state to mesenchymal state and confers metastatic properties as well as treatment resistance. Finding factors to inhibit EMT will greatly improve the prognosis patients. Spermatogenesis associated 2 (SPATA2) was originally isolated from human testis and proved playing a role in spermatogenesis. To date, however, the role of SPATA2 in oncogenesis is unknown. In the current study, by mining the public database and validating in a cohort of collected non–small cell lung cancer (NSCLC) specimens, we uncovered that the expression of SPATA2 positively correlated with the prognosis of patients and was an independent prognosis marker in NSCLC. Functional studies proved that ectopic overexpression of SPATA2 inhibited EMT resulting in impaired motility and invasiveness properties in vitro and metastasis in vivo, and increased radiosensitivity in NSCLC. Mechanistic investigation showed that SPATA2 could suppress the β‐catenin signaling via attenuating DVL1 ubiquitination to achieve the functions. Taken together, the current study revealed an inhibitory role of SPATA2 on EMT and that SPATA2 could be a potential target for therapy of NSCLC. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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