Altered static and dynamic indices of intrinsic brain activity in patients with subcortical ischemic vascular disease: a resting-state functional magnetic resonance imaging analysis.
Purpose: To explore the static and dynamic characteristics of intrinsic brain activity (IBA) in subcortical ischemic vascular disease (SIVD) patients with or without cognitive impairment. Methods: In total, 90 participants were recruited, including 32 SIVD patients with cognitive impairment (SIVD-CI...
| Publicado en: | Neuroradiology Vol. 65; no. 5; pp. 923 - 932 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163121901&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163121901 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: May2023 vid: 65 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163121901 162307844 163121901 163121901 10.1007/s00234-023-03135-8 163121901 ppf: 923 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered static and dynamic indices of intrinsic brain activity in patients with subcortical ischemic vascular disease: a resting-state functional magnetic resonance imaging analysis. aug: au: Song, Ziyang Wu, Zhiwei Zhou, Zheping Feng, Mengmeng Liu, Yuanqing Ma, Mengya Chang, Yue Xing, Hanqi Shen, Lan Wang, Yueju Dai, Hui affil: Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China sug: subj: Vascular Diseases Pathology Brain Physiopathology Vascular Diseases Complications Magnetic Resonance Imaging Methods Brain Mapping Evaluation Cognition Disorders Human Male Female Aged Aged, 80 and Over Brain Radiography Neuropsychological Tests Descriptive Statistics Comparative Studies Funding Source Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: To explore the static and dynamic characteristics of intrinsic brain activity (IBA) in subcortical ischemic vascular disease (SIVD) patients with or without cognitive impairment. Methods: In total, 90 participants were recruited, including 32 SIVD patients with cognitive impairment (SIVD-CI, N = 32), 26 SIVD patients with no cognitive impairment (SIVD-NCI, N = 26), and 32 healthy controls (HC, N = 32) matched for age, gender, and education. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning and neuropsychological tests. Amplitude of low-frequency fluctuation (ALFF) was calculated to reflect static alterations of regional IBA. Sliding window analysis was conducted in order to explore the dynamic characteristics. Results: Both SIVD-CI and SIVD-NCI group showed significantly decreased ALFF in left angular gyrus (ANG), whereas SIVD-CI group showed increased ALFF in right superior frontal gyrus (SFG), compared with HCs. Furthermore, SIVD-CI group showed significantly decreased ALFF dynamics (dALFF) in right precuneus (PreCu) and left dorsal anterior cingulate cortex (dACC), compared with HC and SIVD-NCI groups (Gaussian random field–corrected, voxel-level P < 0.001, cluster-level P < 0.05). No dynamic changes were detected between SIVD-NCI group and HC group. The mean ALFF value in left ANG of SIVD-CI group was correlated with the score of delayed memory scale. Conclusion: ANG may be a vulnerable brain region in SIVD patients. Temporal dynamic analysis could serve as a sensitive and promising method to investigate IBA alterations in SIVD patients. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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