Cardiac fibroblasts and mechanosensation in heart development, health and disease.
The term 'mechanosensation' describes the capacity of cells to translate mechanical stimuli into the coordinated regulation of intracellular signals, cellular function, gene expression and epigenetic programming. This capacity is related not only to the sensitivity of the cells to tissue motion, but...
| Publicado en: | Nature Reviews Cardiology Vol. 20; no. 5; pp. 309 - 325 |
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| Autores principales: | , , , , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163167208&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163167208 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17595002 8UU1 jtl: Nature Reviews Cardiology issn: 17595002 maglogo: N pubinfo: dt: May2023 vid: 20 iid: 5 pid: 2579 pub: Springer Nature place: Dordrecht, <Blank> artinfo: ui: 163167208 163167208 NLM36376437 163167208 10.1038/s41569-022-00799-2 NLM36376437 163167208 ppf: 309 ppct: 16 formats: tig: atl: Cardiac fibroblasts and mechanosensation in heart development, health and disease. aug: au: Pesce, Maurizio Duda, Georg N. Forte, Giancarlo Girao, Henrique Raya, Angel Roca-Cusachs, Pere Sluijter, Joost P. G. Tschöpe, Carsten Van Linthout, Sophie affil: Unità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, Milan, Italy sug: ab: The term 'mechanosensation' describes the capacity of cells to translate mechanical stimuli into the coordinated regulation of intracellular signals, cellular function, gene expression and epigenetic programming. This capacity is related not only to the sensitivity of the cells to tissue motion, but also to the decryption of tissue geometric arrangement and mechanical properties. The cardiac stroma, composed of fibroblasts, has been historically considered a mechanically passive component of the heart. However, the latest research suggests that the mechanical functions of these cells are an active and necessary component of the developmental biology programme of the heart that is involved in myocardial growth and homeostasis, and a crucial determinant of cardiac repair and disease. In this Review, we discuss the general concept of cell mechanosensation and force generation as potent regulators in heart development and pathology, and describe the integration of mechanical and biohumoral pathways predisposing the heart to fibrosis and failure. Next, we address the use of 3D culture systems to integrate tissue mechanics to mimic cardiac remodelling. Finally, we highlight the potential of mechanotherapeutic strategies, including pharmacological treatment and device-mediated left ventricular unloading, to reverse remodelling in the failing heart. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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