Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer.
The prognosis of patients with colorectal cancer (CRC) is affected by invasion and metastasis. Leucyl-tRNA synthetase (LARS) was shown to be related to the growth and migration of lung cancer cells. Dickkopf 4 (DKK4) is known as a Wnt/β-catenin pathway inhibitor, and its upregulation was reported in...
| Published in: | BioMed Research International pp. 1 - 11 |
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| Main Authors: | , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
4/15/2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163167811&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163167811 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 4/15/2023 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 163167811 163167811 163167811 10.1155/2023/9057735 163167811 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer. aug: au: Park, Su-Jeong Cho, Jun Gi Han, Sang-Heum Kim, Yu-Mi Pak, Min-Gyoung Roh, Mee-Sook Park, Joo-In affil: Department of Biochemistry, Dong-A University College of Medicine, 32, Daesingongwon-ro, Seo-gu, Busan 49201, Republic of Korea sug: subj: Colorectal Neoplasms Prognosis Tumor Markers, Biological Metabolism RNA, Transfer Analysis Colorectal Neoplasms Surgery Treatment Outcomes Evaluation Wnt Proteins Antagonists and Inhibitors Signal Transduction Carrier Proteins Metabolism Human Cancer Patients Academic Medical Centers South Korea Descriptive Statistics Overall Survival Disease-Free Survival Retrospective Design Funding Source Surgical Patients Colorectal Neoplasms Pathology Immunohistochemistry Staining and Labeling Tissue Array Analysis Male Female Sex Factors Age Factors Histology Neoplasm Invasiveness Neoplasm Metastasis Lymph Nodes Pathology Neoplasm Staging Neoplasm Recurrence, Local Risk Factors Risk Assessment Male Female ab: The prognosis of patients with colorectal cancer (CRC) is affected by invasion and metastasis. Leucyl-tRNA synthetase (LARS) was shown to be related to the growth and migration of lung cancer cells. Dickkopf 4 (DKK4) is known as a Wnt/β-catenin pathway inhibitor, and its upregulation was reported in several cancers. However, the clinical significance of LARS and DKK4 in human CRC has not been clearly defined. We investigated the expression of LARS and DKK4 by immunohistochemical staining in tissue microarrays from 642 primary CRC patients and analyzed the relationship between their expression and the clinicopathological characteristics of CRC patients. LARS and DKK4 expressions were not related to gender, age at surgery, histologic grade, size, tumor location, tumor invasion, or metastasis, but LARS expression was significantly correlated with TNM stage, N stage, and lymph node metastasis. DKK4 expression was inversely related to the TNM stage and N stage. Survival analysis demonstrated that the OS and DFS in the LARS high expression group were not different compared to the LARS low expression group. OS and DFS in the DKK4 high expression group were significantly higher than in the DKK4 low expression group. In addition, OS and DFS in the group with the combination of the LARS high/DKK4 low expression were significantly lower than in the LARS high/DKK4 high expression group. The low expression of DKK4 alone can be used as a predictor of relapse in CRC patients. In addition, DKK4 low expression in the case of LARS high expression can be used as a poor prognostic factor in CRC patients. Thus, our findings suggest that DKK4 alone or in combination with LARS at diagnosis may be a useful prognostic factor for CRC. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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