Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis.
Background: Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are part of a spectrum of Lewy body disorders, who exhibit a range of cognitive and gait impairments. Cognitive-motor interactions can be examined by performing a cognitive task while walking and quantified by a dual task cost...
| Publicado en: | Frontiers in Aging Neuroscience Vol. 15; pp. 1 - 13 |
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| Autores principales: | , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
4/5/2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163200396&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163200396 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 4/5/2023 vid: 15 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 163200396 163200396 163200396 10.3389/fnagi.2023.1088050 163200396 ppf: 1 ppct: 12 formats: tig: atl: Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis. aug: au: Fatokun, Ipinuoluwakiye Gee, Myrlene Nelles, Krista Fang Ba Dadar, Mahsa Duchesne, Simon Sharma, Breni Masellis, Mario Black, Sandra E. Almeida, Quincy J. Smith, Eric E. Pieruccini-Faria, Frederico Montero-Odasso, Manuel Camicioli, Richard affil: Department of Medicine, Division of Neurology, University of Alberta, Edmonton, AB, Canada sug: subj: Gait Analysis Cognition Evaluation Task Performance and Analysis Lewy Body Disease Pathology White Matter Pathology Parkinson Disease Pathology Magnetic Resonance Imaging Human Exploratory Research Multicenter Studies Comparative Studies Walking Speed Evaluation Mild Cognitive Impairment Age Factors Ontario Alberta Scales Neuropsychological Tests Questionnaires Descriptive Statistics Data Analysis Software One-Way Analysis of Variance Chi Square Test Middle Age Aged Aged, 80 and Over Female Male Funding Source Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Background: Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are part of a spectrum of Lewy body disorders, who exhibit a range of cognitive and gait impairments. Cognitive-motor interactions can be examined by performing a cognitive task while walking and quantified by a dual task cost (DTC). White matter hyperintensities (WMH) on magnetic resonance imaging have also been associated with both gait and cognition. Our goal was to examine the relationship between DTC and WMH in the Lewy body spectrum, hypothesizing DTC would be associated with increased WMH volume. Methods: Seventy-eight participants with PD, PD with mild cognitive impairment (PD-MCI), PD with dementia or DLB (PDD/DLB), and 20 cognitively unimpaired participants were examined in a multi-site study. Gait was measured on an electronic walkway during usual gait, counting backward, animal fluency, and subtracting sevens. WMH were quantified from magnetic resonance imaging using an automated pipeline and visual rating. A median split based on DTC was performed. Models included age as well as measures of global cognition and cardiovascular risk. Results: Compared to cognitively unimpaired participants, usual gait speed was lower and DTC was higher in PD-MCI and PDD/DLB. Low DTC participants had higher usual gait speed. WMH burden was greater in high counting DTC participants. Frontal WMH burden remained significant after adjusting for age, cardiovascular risk and global cognition. Conclusion: Increased DTC was associated with higher frontal WMH burden in Lewy body disorders after adjusting for age, cardiovascular risk, and global cognition. Higher DTC was associated with age. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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