Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability.
Aberrant responses to frustration are central mechanisms of pediatric irritability, which is a common reason for psychiatric consultation and a risk factor for affective disorders and suicidality. This pilot study aimed to characterize brain network configuration during and after frustration and tes...
| Publicado en: | Journal of the American Academy of Child & Adolescent Psychiatry Vol. 62; no. 6; pp. 684 - 696 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | Artículo |
| Publicado: |
Elsevier B.V.
Jun2023
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=163292715&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 163292715 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08908567 JAM jtl: Journal of the American Academy of Child & Adolescent Psychiatry issn: 08908567 maglogo: N pubinfo: dt: Jun2023 vid: 62 iid: 6 pid: 467 pub: Elsevier B.V. artinfo: ui: 163292715 10.1016/j.jaac.2022.11.009 ppf: 684 ppct: 12 formats: tig: atl: Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability. aug: au: Linke, Julia O. Haller, Simone P. Xu, Ellie P. Nguyen, Lynn T. Chue, Amanda E. Botz-Zapp, Christian Revzina, Olga Perlstein, Samantha Ross, Andrew J. Tseng, Wan-Ling Shaw, Philip Brotman, Melissa A. Pine, Daniel S. Gotts, Stephen J. Leibenluft, Ellen Kircanski, Katharina affil: Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland Yale Child Study Center, Yale School of Medicine, Yale University, New Haven, Connecticut Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland su: Individual differences Reward (Psychology) Large-scale brain networks Functional magnetic resonance imaging Irritability (Psychology) sug: subj: Individual differences Reward (Psychology) Large-scale brain networks Functional magnetic resonance imaging Irritability (Psychology) keyword: fMRI frustration graph-theory irritability prediction fMRI frustration graph-theory irritability prediction ab: Aberrant responses to frustration are central mechanisms of pediatric irritability, which is a common reason for psychiatric consultation and a risk factor for affective disorders and suicidality. This pilot study aimed to characterize brain network configuration during and after frustration and test whether characteristics of networks formed during or after frustration relate to irritability. During functional magnetic resonance imaging, a transdiagnostic sample enriched for irritability (N = 66, mean age = 14.0 years, 50% female participants) completed a frustration-induction task flanked by pretask and posttask resting-state scans. We first tested whether and how the organization of brain regions (ie, nodes) into networks (ie, modules) changes during and after frustration. Then, using a train/test/held-out procedure, we aimed to predict past-week irritability from global efficiency (E glob) (ie, capacity for parallel information processing) of these modules. Two modules present in the baseline pretask resting-state scan (one encompassing anterior default mode and temporolimbic regions and one consisting of frontoparietal regions) contributed most to brain circuit reorganization during and after frustration. Only E glob of modules in the posttask resting-state scans (ie, after frustration) predicted irritability symptoms. Self-reported irritability was predicted by E glob of a frontotemporal-limbic module. Parent-reported irritability was predicted by E glob of ventral-prefrontal-subcortical and somatomotor-parietal modules. These pilot results suggest the importance of the postfrustration recovery period in the pathophysiology of irritability. E glob in 3 specific posttask modules, involved in emotion processing, reward processing, or motor function, predicted irritability. These findings, if replicated, could represent specific intervention targets for irritability. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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