The recombined memory: associative inference in Alzheimer's disease.
Background: Associative inference refers to an adaptive ability that allows flexible recombination of information acquired during previous experiences to make new connections that they have not directly experienced. This cognitive ability has been widely associated with the hippocampus. Aims: We inv...
| Publicado en: | Aging Clinical & Experimental Research Vol. 35; no. 5; pp. 1005 - 1014 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163414476&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163414476 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15940667 2WMP jtl: Aging Clinical & Experimental Research issn: 15940667 maglogo: N pubinfo: dt: May2023 vid: 35 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163414476 162139209 163414476 163414476 10.1007/s40520-023-02372-4 163414476 ppf: 1005 ppct: 9 formats: tig: atl: The recombined memory: associative inference in Alzheimer's disease. aug: au: El Haj, Mohamad Moustafa, Ahmed A. Robin, Frédérique Chapelet, Guillaume affil: Laboratoire de Psychologie Des Pays de La Loire (LPPL-EA 4638), Nantes Université, Univ Angers, 44000, Nantes, France sug: subj: Memory Alzheimer's Disease Diagnosis Task Performance and Analysis Human Female Male Aged Cognitive Flexibility Aged: 65+ years Female Male ab: Background: Associative inference refers to an adaptive ability that allows flexible recombination of information acquired during previous experiences to make new connections that they have not directly experienced. This cognitive ability has been widely associated with the hippocampus. Aims: We investigated associative inference in patients with Alzheimer's disease and control participants. Methods: The task has two phases. In the training phase, participants learned to encode overlapping pairs of objects (AB + BC). In the test phase, participants were invited to retrieve previously see associations (i.e., AB, BC) as well as novel associations between the previously exposed objects (i.e., AC). In addition, we test the relationship between associative inference and cognitive flexibility. Results: Analysis demonstrated lower associative inference in AD patients than in control participants. Interestingly, performance on the associative inference task was significantly correlated with low performance on a cognitive flexibility task in AD patients. Discussion: Our findings demonstrate a compromise of the ability to flexibly combine new representations from prior memories in AD, which is likely related to the hippocampal dysfunction in AD. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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