Altered Associations Between Motivated Performance and Frontostriatal Functional Connectivity During Reward Anticipation in Schizophrenia.
Background and hypothesis The neuronal mechanisms that underlie deficits in effort cost computation in schizophrenia (SZ) are poorly understood. Given the role of frontostriatal circuits in valence-oriented motivation, we hypothesized that these circuits are either dysfunctional in SZ or do not appr...
| Publicado en: | Schizophrenia Bulletin Vol. 49; no. 3; pp. 717 - 726 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
May2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163492142&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163492142 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 05867614 2CZ jtl: Schizophrenia Bulletin issn: 05867614 maglogo: N pubinfo: dt: May2023 vid: 49 iid: 3 pid: 622 pub: Oxford University Press / USA artinfo: ui: 163492142 163492142 163492142 10.1093/schbul/sbac204 163492142 ppf: 717 ppct: 9 formats: tig: atl: Altered Associations Between Motivated Performance and Frontostriatal Functional Connectivity During Reward Anticipation in Schizophrenia. aug: au: Smucny, Jason Hanks, Timothy D Lesh, Tyler A O'Reilly, Randall C Carter, Cameron S affil: Department of Psychiatry and Behavioral Sciences, University of California , Davis, CA sug: subj: Basal Ganglia Physiopathology Schizophrenia Risk Factors Motivation Methods Functional Connectivity Evaluation Task Performance and Analysis Reward Risk Assessment Human Comparative Studies Regression Predictive Value of Tests Schizophrenia Diagnosis Magnetic Resonance Imaging Funding Source ab: Background and hypothesis The neuronal mechanisms that underlie deficits in effort cost computation in schizophrenia (SZ) are poorly understood. Given the role of frontostriatal circuits in valence-oriented motivation, we hypothesized that these circuits are either dysfunctional in SZ or do not appropriately predict behavior in SZ when task conditions are difficult and good performance is rewarded. Study design A total of 52 people with recent onset SZ-spectrum disorders and 48 healthy controls (HCs) performed a 3T fMRI task with 2 valence conditions (rewarded vs neutral) and 2 difficulty conditions. Frontostriatal connectivity was extracted during the cue (anticipatory) phase. Individual behavior was fit using a drift-diffusion model, allowing the performance parameter, drift rate (DR), to vary between task conditions. Three models were examined: A group × condition model of DR, a group × condition model of connectivity, and a regression model of connectivity predicting DR depending on group and condition. Study results DRs showed the expected positive correlation with accuracy and a negative association with reaction time. The SZ group showed a deficit in DR but did not differ in overall connectivity or show a valence-specific deficit in connectivity. Significant group × valence × difficulty interactions, however, were observed on the relationship between right dorsolateral prefrontal (DLPFC)-striatal connectivity and DR (DLPFC-Caudate: F = 10.92, P FDR = .004; DLPFC-Putamen: F = 5.14, P FDR = .048) driven by more positive relationships between DR and connectivity during cues for the difficult-rewarded condition in HCs compared to SZ. Conclusions These findings suggest that frontostriatal connectivity is less predictive of performance in SZ when task difficulty is increased and a reward incentive is applied. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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