Rhodium Boryl Complexes in the Catalytic, Terminal Functionalization of Alkanes.

A series of studies have been conducted by experimental and theoretical methods on the synthesis, structures, and reactions of Cp*Rh boryl complexes that are likely intermediates in the rhodium- catalyzed regioselective, terminal functionalization of alkanes. The photochemical reaction of Cp*Rh(n-CM...

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Publicado en:Journal of the American Chemical Society Vol. 127; no. 8; pp. 2538 - 2553
Autores principales: Hartwig, John F., Cook, Kevin S., Hapke, Marko, Incarvito, Christopher D., Yubo Fan, Webster, Charles Edwin, Hall, Michael B.
Formato: Artículo
Publicado: American Chemical Society 3/2/2005
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Acceso en línea:Ver este registro en EBSCOhost
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      dt: 3/2/2005
      vid: 127
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      pub: American Chemical Society
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        16361026
        10.1021/ja045090c
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        atl: Rhodium Boryl Complexes in the Catalytic, Terminal Functionalization of Alkanes.
      aug:
        au:
          Hartwig, John F.
          Cook, Kevin S.
          Hapke, Marko
          Incarvito, Christopher D.
          Yubo Fan
          Webster, Charles Edwin
          Hall, Michael B.
        affil:
          Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107
          Department of Chemistry, Texas A&M University, College Station, Texas 77843-3255
      su:
        Aliphatic compounds
        Alkanes
        Aromatic compounds
        Density functionals
        Nuclear magnetic resonance spectroscopy
        Spectrum analysis
      sug:
        subj:
          Aliphatic compounds
          Alkanes
          Aromatic compounds
          Density functionals
          Nuclear magnetic resonance spectroscopy
          Spectrum analysis
      ab: A series of studies have been conducted by experimental and theoretical methods on the synthesis, structures, and reactions of Cp*Rh boryl complexes that are likely intermediates in the rhodium- catalyzed regioselective, terminal functionalization of alkanes. The photochemical reaction of Cp*Rh(n-CMe) with pinacolborane (HBpin) generates the bisboryl complex Cp*Rh(H)(Bpin) (2), which reacts with neat HBpin to generate Cp*Rh(H)(Bpin) (3). X-ray diffraction, density functional theory (DFT) calculations, and NMR spectroscopy suggest a weak, but measurable, B-H bonding interaction. Both 2 and 3 dissociate HBpin and coordinate PEt or P(p-Tol) to generate the conventional rhodium(III) species Cp*Rh(PEt)(H)(Bpin) (4) and Cp*Rh[P(p-tol)](Bpin) 5). Compounds 2 and 3 also react with alkanes and arenes to form alkyl- and arylboronate esters at temperatures similar to or below those of the catalytic borylation of alkanes and arenes. Further, these compounds were observed directly in catalytic reactions. The enthalpies and free energies for generation of the 16-electron intermediate and for the C-H bond cleavage and B-C bond formation have been calculated with DFT. These results strongly suggest that the C-H bond cleavage process occurs by a metal-assisted u-bond metathesis mechanism to generate a borane complex that isomerizes if necessary to place the alkyl group cis to the boryl group. This complex with cis boryl and alkyl groups then undergoes B-C bond formation by a second a-bond metathesis to generate the final functionalized product.
      pubtype: Academic Journal
      doctype: Article
      src: R
    language: English
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