Intermittent theta burst stimulation to the left dorsolateral prefrontal cortex improves working memory of subjects with methamphetamine use disorder.
Background: Repetitive transcranial magnetic stimulation has been employed to treat drug dependence, reduce drug use and improve cognition. The aim of the study was to analyze the effectiveness of intermittent theta-burst stimulation (iTBS) on cognition in individuals with methamphetamine use disord...
| Publicado en: | Psychological Medicine Vol. 53; no. 6; pp. 2427 - 2437 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Apr2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163612978&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163612978 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Apr2023 vid: 53 iid: 6 pid: 15979 pub: Cambridge University Press artinfo: ui: 163612978 163612978 163612978 10.1017/S003329172100430X 163612978 ppf: 2427 ppct: 10 formats: tig: atl: Intermittent theta burst stimulation to the left dorsolateral prefrontal cortex improves working memory of subjects with methamphetamine use disorder. aug: au: Zhang, Yi Ku, Yixuan Sun, Junfeng Daskalakis, Zafiris J. Yuan, Ti-Fei affil: Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China sug: subj: Methamphetamine Adverse Effects Substance Use Disorders Drug Therapy Transcranial Magnetic Stimulation Dorsolateral Prefrontal Cortex Physiology Memory, Short Term Substance Dependence Prevention and Control Clinical Effectiveness Evaluation Cognition Reaction Time Electroencephalography Discrimination Prefrontal Cortex Human Male Female Adult Data Analysis Software Descriptive Statistics Funding Source Adolescence Young Adult Middle Age Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Male Female ab: Background: Repetitive transcranial magnetic stimulation has been employed to treat drug dependence, reduce drug use and improve cognition. The aim of the study was to analyze the effectiveness of intermittent theta-burst stimulation (iTBS) on cognition in individuals with methamphetamine use disorder (MUD). Methods: This was a secondary analysis of 40 MUD subjects receiving left dorsolateral prefrontal cortex (L-DLPFC) iTBS or sham iTBS for 20 times over 10 days (twice-daily). Changes in working memory (WM) accuracy, reaction time, and sensitivity index were analyzed before and after active and sham rTMS treatment. Resting-state EEG was also acquired to identify potential biological changes that may relate to any cognitive improvement. Results: The results showed that iTBS increased WM accuracy and discrimination ability, and improved reaction time relative to sham iTBS. iTBS also reduced resting-state delta power over the left prefrontal region. This reduction in resting-state delta power correlated with the changes in WM. Conclusions: Prefrontal iTBS may enhance WM performance in MUD subjects. iTBS induced resting EEG changes raising the possibility that such findings may represent a biological target of iTBS treatment response. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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