Longitudinal changes in quantitative magnetic resonance imaging metrics in children and young adults with autoimmune liver disease.
Purpose: To assess longitudinal changes in quantitative MRI metrics in pediatric and young adult patients with autoimmune liver disease (AILD). Methods: This prospective, IRB-approved study included 20 children and young adults (median age = 15 years) with primary sclerosing cholangitis (PSC)/autoim...
| Publicado en: | Abdominal Radiology Vol. 48; no. 6; pp. 1933 - 1945 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163614094&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163614094 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jun2023 vid: 48 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163614094 161927974 10.1007/s00261-022-03733-9 163614094 ppf: 1933 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Longitudinal changes in quantitative magnetic resonance imaging metrics in children and young adults with autoimmune liver disease. aug: au: Mahalingam, Neeraja Trout, Andrew T. Zhang, Bin Castro-Rojas, Cyd Miethke, Alexander G. Dillman, Jonathan R. affil: Department of Radiology, Cincinnati Children's Hospital Medical Center, 250 Albert Sabin Way, 45229, Cincinnati, OH, USA sug: ab: Purpose: To assess longitudinal changes in quantitative MRI metrics in pediatric and young adult patients with autoimmune liver disease (AILD). Methods: This prospective, IRB-approved study included 20 children and young adults (median age = 15 years) with primary sclerosing cholangitis (PSC)/autoimmune sclerosing cholangitis (ASC) and 19 (median age = 17 years) with autoimmune hepatitis (AIH). At a field strength of 1.5-T, T2*-corrected T1 mapping (cT1), 3D fast spin-echo MRCP, and 2D gradient recalled echo MR elastography (MRE) were performed at baseline, one year, and two years. cT1 and quantitative MRCP were processed using LiverMultiScan and MRCP + , respectively (Perspectum Ltd, Oxford, UK). Linear mixed models were used to assess longitudinal changes in quantitative MRI metrics. Spearman rank-order correlation was used to assess relationships between changes in quantitative MRI metrics. Results: Changes in quantitative MRI metrics greater than established repeatability coefficients were measured in six (cT1) and five (MRE) patients with PSC/ASC as well as in six patients (cT1 and MRE) with AIH, although linear mixed models identified no significant changes for the subgroups as a whole. For PSC/ASC, there were positive correlations between change in liver stiffness and changes in bile duct strictures (ρ = 0.68; p = 0.005) and bile duct dilations (ρ = 0.70; p = 0.004) between baseline and Year 2. Conclusion: On average, there were no significant changes in quantitative MRI metrics over a two-year period in children and young adults with AILD. However, worsening cholangiopathy was associated with increasing liver stiffness by MRE in patients with PSC/ASC. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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