Extracellular volume fraction obtained by dual-energy CT depicting the etiological differences of liver fibrosis.
Purpose: To assess etiological differences in extracellular volume fraction (ECV) and evaluate its influence on staging performance. Methods: A total of 166 patients with normal liver (n = 14) and chronic liver disease related to viral hepatitis (n = 71), alcohol (n = 44), and nonalcoholic steatohep...
| Publicado en: | Abdominal Radiology Vol. 48; no. 6; pp. 1975 - 1987 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163614106&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163614106 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Jun2023 vid: 48 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163614106 162527461 10.1007/s00261-023-03873-6 163614106 ppf: 1975 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Extracellular volume fraction obtained by dual-energy CT depicting the etiological differences of liver fibrosis. aug: au: Ozaki, Kumi Ohtani, Takashi Ishida, Shota Higuchi, Shohei Ishida, Tomokazu Takahashi, Kouki Matta, Yuki KImura, Hirohiko Gabata, Toshifumi affil: Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, 910-1193, Fukui, Japan sug: ab: Purpose: To assess etiological differences in extracellular volume fraction (ECV) and evaluate its influence on staging performance. Methods: A total of 166 patients with normal liver (n = 14) and chronic liver disease related to viral hepatitis (n = 71), alcohol (n = 44), and nonalcoholic steatohepatitis (NASH) (n = 37) underwent dual-energy CT (DECT) of the liver (5-min equilibrium-phase images) between January 2020 and July 2022. The iodine densities of the parenchyma and aorta were measured and ECV was calculated. Comparisons of ECV between each etiology and METAVIR fibrosis stage were statistically analyzed (p < 0.05). Results: ECV in each etiology and all patients significantly increased with higher fibrosis stage (p < 0.001) and showed a strong or moderate correlation with fibrosis stage (Spearman's ρ; all patients, 0.701; viral hepatitis, 0.638; alcoholic, 0.885; NASH, 0.791). In stages F2–F4, ECV in alcoholic liver disease was significantly larger than those for viral hepatitis and NASH (p < 0.05); however, no significant difference in stage F1 was found among the three etiologies. The cutoff values and areas under the receiver operating characteristic curve (AUC-ROCs) for discriminating fibrosis stage (≥ F1– ≥ F4) were higher for alcohol (cutoff values and AUC-ROC; 20.1% and 0.708 for ≥ F1, 23.8% and 0.990 for ≥ F2, 24.3% and 0.968 for ≥ F3, and 26.6% and 0.961 for ≥ F4, respectively) compared with those for the others. Conclusion: ECV in alcoholic liver disease is higher than that in other etiologies in the advanced stages of fibrosis, and etiological differences in ECV affect the staging performance of fibrosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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