Altered thalamic volume in patients with mild autonomous cortisol secretion: a structural brain MRI study.
Purpose: To compare thalamic volume and cognitive functions of patients with mild autonomous cortisol secretion (MACS) with control subjects and patients with overt Cushing's syndrome (CS). Methods: In this cross-sectional study, volumes of regions of interest were assessed using 3 T magnetic resona...
| Publicado en: | Neuroradiology Vol. 65; no. 6; pp. 1037 - 1052 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163634079&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163634079 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jun2023 vid: 65 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 163634079 163368255 163634079 163634079 10.1007/s00234-023-03156-3 163634079 ppf: 1037 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered thalamic volume in patients with mild autonomous cortisol secretion: a structural brain MRI study. aug: au: Sulu, Cem Koca, Oguzhan Icli, Tevhide Betul Oz, Ahmet Kargin, Osman Aykan Durcan, Emre Sahin, Serdar Arslan, Serdar Turan, Senol Kadioglu, Pinar Ozkaya, Hande Mefkure affil: Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Türkiye sug: subj: Thalamus Anatomy and Histology Adrenal Gland Neoplasms Physiopathology Hydrocortisone Metabolism Cognition Cushing's Syndrome Physiopathology Human Cross Sectional Studies Magnetic Resonance Imaging Methods Questionnaires Data Analysis Software Descriptive Statistics Sociodemographic Factors ab: Purpose: To compare thalamic volume and cognitive functions of patients with mild autonomous cortisol secretion (MACS) with control subjects and patients with overt Cushing's syndrome (CS). Methods: In this cross-sectional study, volumes of regions of interest were assessed using 3 T magnetic resonance imaging and a voxel-based morphometry approach in 23 patients with MACS, 21 patients with active CS, 27 patients with CS in remission, and 21 control subjects. Cognitive functions were assessed using validated questionnaires. Results: Patients with MACS had smaller left thalamic (F = 3.8, p = 0.023), left posterior thalamic (F = 4.9, p = 0.01), left medial thalamic (F = 4.7, p = 0.028), and right lateral thalamic (F = 4.1, p = 0.025) volumes than control subjects. Patients with active CS also had smaller left thalamic (F = 3.8, p = 0.044), left posterior thalamic (F = 4.9, p = 0.007), left medial thalamic (F = 4.7, p = 0.006), and right lateral thalamic (F = 4.1, p = 0.042) volumes compared to controls. Patients with CS in remission had smaller left medial (F = 4.7, p = 0.030) and right lateral thalamic (F = 4.1, p = 0.028) volumes than controls. Neuropsychological tests showed no difference between the groups. Conclusion: MACS may decrease thalamic volume. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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