Co-infection of COVID-19 patients with atypical bacteria: A study based in Jordan.
Objective: The aim of this work was to know the prevalence of Chlamydophila pneumoniae and Mycoplasma pneumoniae in coronavirus disease 2019 (COVID-19) patients in Jordan. Also, to assess a TaqMan real-time polymerase chain reaction (PCR) assay in detecting these two bacteria. Methods: This is a ret...
| Published in: | Pharmacy Practice (1886-3655) Vol. 21; no. 1; pp. 1 - 6 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Centro de Investigaciones y Publicaciones Farmaceuticas S.L.
Jan-Mar2023
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=163658584&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 163658584 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1885642X 3EAU jtl: Pharmacy Practice (1886-3655) issn: 1885642X maglogo: N pubinfo: dt: Jan-Mar2023 vid: 21 iid: 1 pid: 36266 pub: Centro de Investigaciones y Publicaciones Farmaceuticas S.L. artinfo: ui: 163658584 163658584 163658584 10.18549/PharmPract.2023.1.2753 163658584 ppf: 1 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Co-infection of COVID-19 patients with atypical bacteria: A study based in Jordan. aug: au: Alsayed, Ahmad R. Hasoun, Luai Khader, Heba A. Abu-Samak, Mahmoud S. Al-Shdifat, Laith M. H. Al-shammari, Basheer Al Maqbali, Mohammed affil: Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931-166, Jordan sug: subj: COVID-19 Coinfection Epidemiology Chlamydophila Infections Epidemiology Pneumonia, Mycoplasma Epidemiology Polymerase Chain Reaction Methods Chlamydophila Infections Diagnosis Pneumonia, Mycoplasma Diagnosis Human Jordan Retrospective Design Nasopharynx Microbiology Chlamydophila Pneumoniae Analysis Mycoplasma Analysis Bacterial Proteins Analysis Correlation Coefficient Descriptive Statistics Prevalence ab: Objective: The aim of this work was to know the prevalence of Chlamydophila pneumoniae and Mycoplasma pneumoniae in coronavirus disease 2019 (COVID-19) patients in Jordan. Also, to assess a TaqMan real-time polymerase chain reaction (PCR) assay in detecting these two bacteria. Methods: This is a retrospective study performed over the last five months of the 2021. All nasopharyngeal specimens from COVID-19 patients were tested for C. pneumonia, and M. pneumoniae. The C. pneumoniae Pst-1 gene and M. pneumoniae P1 cytadhesin protein gene were the targets. Results: In this study, 14 out of 175 individuals with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (8.0%) were co-infected with C. pneumoniae or M. pneumoniae. Co-infection with SARS-CoV-2 and C. pneumoniae was reported in 5 (2.9%) patients, while 9 (5.1%) patients had M. pneumoniae and SARS-CoV-2 co-infection. The mean (± std) of the correlation coefficient of the calibration curve for real-time PCR analysis was -0.993 (± 0.001) for C. pneumoniae and -0.994 (± 0.003) for M. pneumoniae. The mean amplification efficiencies of C. pneumoniae and M. Pneumoniae were 187.62% and 136.86%, respectively. Conclusion: In this first study based in Jordan, patients infected with COVID-19 have a low rate of atypical bacterial co-infection. However, clinicians should suspect co-infections with both common and uncommon bacteria in COVID-19 patients. Large prospective investigations are needed to give additional insight on the true prevalence of these co-infections and their impact on the clinical course of COVID-19 patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|