Prospective Memory Function Predicts Future Cognitive Decline and Incident Dementia.
Objectives This study aimed to test whether prospective memory (PM) was an early cognitive marker of future cognitive decline and incident dementia using longitudinal data spanning 8 years from the Sydney Memory and Ageing Study. Methods At baseline, 121 participants aged 72–91 years were tested in...
| Publicado en: | Journals of Gerontology Series B: Psychological Sciences & Social Sciences Vol. 78; no. 5; pp. 819 - 830 |
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| Autores principales: | , , , , , |
| Formato: | Artículo |
| Publicado: |
Oxford University Press / USA
May2023
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=163670011&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 163670011 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10795014 JGB jtl: Journals of Gerontology Series B: Psychological Sciences & Social Sciences issn: 10795014 maglogo: N pubinfo: dt: May2023 vid: 78 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 163670011 10.1093/geronb/gbad027 ppf: 819 ppct: 11 formats: tig: atl: Prospective Memory Function Predicts Future Cognitive Decline and Incident Dementia. aug: au: Browning, Catherine A Thompson, Claire L Kochan, Nicole A Brodaty, Henry Sachdev, Perminder S Henry, Julie D affil: Centre for Healthy Brain Ageing (CHeBA), Division of Psychiatry and Mental Health, UNSW Medicine, UNSW Sydney , Sydney, New South Wales , Australia College of Psychology, Central Queensland University , Rockhampton, Queensland , Australia Dementia Centre for Research Collaboration (DCRC), School of Psychiatry, UNSW Sydney , Sydney, New South Wales , Australia Neuropsychiatric Institute (NPI), Prince of Wales Hospital , Randwick, New South Wales , Australia School of Psychology, The University of Queensland , Brisbane, Queensland , Australia su: Retrospective studies Episodic memory Classification of mental disorders Dementia risk factors Diagnosis of dementia Cognition disorders Mild cognitive impairment Regression analysis Neuropsychological tests Cognitive aging Memory disorders Dementia Research funding Longitudinal method Proportional hazards models sug: subj: Retrospective studies Episodic memory Classification of mental disorders Dementia risk factors Diagnosis of dementia Cognition disorders Mild cognitive impairment Regression analysis Neuropsychological tests Cognitive aging Memory disorders Dementia Research funding Longitudinal method Proportional hazards models keyword: Everyday memory Neurocognitive disorder Spontaneous retrieval deficit Virtual Week Everyday memory Neurocognitive disorder Spontaneous retrieval deficit Virtual Week ab: Objectives This study aimed to test whether prospective memory (PM) was an early cognitive marker of future cognitive decline and incident dementia using longitudinal data spanning 8 years from the Sydney Memory and Ageing Study. Methods At baseline, 121 participants aged 72–91 years were tested in PM using a validated PM task, Virtual Week, which included time- and event-based tasks presented with varying regularity. Responses were scored "Correct" if completed accurately and "Missed" if the target was not remembered at any time. Measures of cognition were taken at baseline and 2-year intervals over 8 years. Dementia diagnoses were made by expert consensus panels using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria. Linear mixed models and Cox proportional hazards regression models were used to analyze the data, controlling for potential confounds. Results Both decreased PM accuracy and missed PM responses were associated with rate of cognitive decline measured by Mini-Mental State Examination over 8 years and global cognitive decline over 4 years. Risk of incident dementia increased with poorer baseline PM ability and missed responses. These effects remained significant after controlling for baseline cognition and were strongest for event-based and regular PM tasks. Discussion PM is a sensitive early marker of future cognitive decline and risk of incident dementia. PM tasks supported by spontaneous retrieval (event-based) and those with lower retrospective memory demands (regular tasks) function as particularly sensitive predictors. In other words, deficits in performing less effortful PM tasks best predicted cognitive decline. These findings may encourage clinicians to incorporate PM tasks in clinical assessments. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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