The Development of Mental Health Difficulties in Young People With and Without Developmental Language Disorder: A Gene–Environment Interplay Study Using Polygenic Scores.
Purpose: Young people with developmental language disorder (DLD) have poorer mental health than those without DLD. However, not all young people with DLD are equally affected; some have more mental health difficulties than others. What explains these differences remains unclear. Method: Data from a...
| Published in: | Journal of Speech, Language & Hearing Research Vol. 66; pp. 1639 - 1658 |
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| Main Authors: | , , , , |
| Format: | Article |
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American Speech-Language-Hearing Association
May2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=163674958&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 163674958 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10924388 1SM jtl: Journal of Speech, Language & Hearing Research issn: 10924388 maglogo: N pubinfo: dt: May2023 vid: 66 pid: 42 pub: American Speech-Language-Hearing Association artinfo: ui: 163674958 10.1044/2023_JSLHR-22-00664 ppf: 1639 ppct: 19 formats: fmt: @attributes: type: P size: 998KB tig: atl: The Development of Mental Health Difficulties in Young People With and Without Developmental Language Disorder: A Gene–Environment Interplay Study Using Polygenic Scores. aug: au: Toseeb, Umar Vincent, John Oginni, Olakunle A. Asbury, Kathryn Newbury, Dianne F. affil: Department of Education, University of York, United Kingdom. Institute of Psychiatry, Psychology, and Neuroscience, King’s College London, United Kingdom. Department of Mental Health, Obafemi Awolowo University, Ile-Ife, Nigeria. Department of Medical and Biological Sciences, Oxford Brookes University, United Kingdom. su: Mental illness genetics Mental illness risk factors Home environment Language acquisition Social classes Language disorders Mental illness Adolescence Research Life course approach Risk assessment Research funding Descriptive statistics Genotypes Questionnaires Longitudinal method Secondary analysis Poisson distribution Disease complications sug: subj: Mental illness genetics Mental illness risk factors Home environment Language acquisition Social classes Language disorders Mental illness Adolescence Research Life course approach Risk assessment Research funding Descriptive statistics Genotypes Questionnaires Longitudinal method Secondary analysis Poisson distribution Disease complications ab: Purpose: Young people with developmental language disorder (DLD) have poorer mental health than those without DLD. However, not all young people with DLD are equally affected; some have more mental health difficulties than others. What explains these differences remains unclear. Method: Data from a community cohort study, the Avon Longitudinal Study of Parents and Children, were analyzed to investigate genetic and environmental influences on the development of mental health difficulties at five time points from childhood (7 years) to adolescence (16 years) in 6,387 young people (8.7% with DLD). Regression and latent class models were fitted to the data. Results: Polygenic scores (PGSs), indices of genetic risk, for common psychiatric disorders (major depressive disorder, anxiety disorder, and attention deficit hyperactivity disorder) predicted mental health difficulties in both groups (with and without DLD). The presence of DLD, in some instances, amplified mental health difficulties for those with high genetic risk for common psychiatric disorders. Subgroups of children with similar developmental trajectories of mental health difficulties were identified. Young people with DLD were more likely than those without DLD to follow mental health subgroups characterized by consistently high levels of difficulties during development. PGSs, socioeconomic status, and the early home environment distinguished subgroups with low mental health difficulties from those characterized by high levels of difficulties, but these effects did not differ based on DLD status. Conclusions: These findings suggest that, for the most part, both genetic and environmental risk affect the development of mental health difficulties in a cumulative way for young people with DLD (and those without). Some analysis did, however, suggest that genetic risk for common psychiatric disorders might manifest more strongly in those with DLD compared with those without DLD. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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